Modulo 424B5 Guardion Health Sciences

Archiviato ai sensi della Regola 424(b)(5)

Dichiarazione di registrazione n. 333-248895

SUPPLEMENTO PROSPETTO

(ToProspetto del 24 settembre 2020)

GuardionHealth Sciences, Inc.

Upto $25,000,000

CommonStock

Wehave entered into an equity distribution agreement (the “Sales Agreement”) with Maxim Group LLC (“Maxim”) andRoth Capital Partners, LLC (“Roth”, or collectively with Maxim, the “Distribution Agents”), dated January 28,2022, relating to the sale of shares of our common stock offered by this prospectus supplement and the accompanying prospectus. Asof the date of this prospectus supplement, we have issued and sold an aggregate of 7,608,674 shares of our common stock, par value $0.001per share, for aggregate gross proceeds of approximately $35,000,000 pursuant to Sales Agreements under a Registration Statement on FormS-3 (File No. 333-248895) (the “Registration Statement”), utilizing prior prospectus supplements dated January 8, 2021 andJanuary 28, 2021. In accordance with the terms of the Sales Agreement, we may offer and sell shares of our common stock having an aggregateoffering price of up to $25,000,000 from time to time through a Distribution Agent, acting as agent under this prospectus supplementand the accompanying prospectus.

Salesof communis stirpis nostrae, si quis, sub prospectus hoc supplemento et prospectus comitatus, quavis methodo permissus erit, quae "in foro oblatione" habetur, ut in Regula 415 sub Actus Securitatum anni 1933 definita est, ut emendatum (de "Securities Act. "). Si nos et Agentes Distributiones in quamlibet modum distributionis consentiunt praeter venditiones portionum communis stirpis nostrae intoThe Nasdaq Capital Market vel alius mercatus mercatus in Civitatibus Foederatis existentibus in annona mercatus, ulteriorem prospectussupplendum praebemus omnia informationes de tali oblatio. secundum regulam 424 (b) sub Securitatibus Act. Distributio Agentsare non requiritur ad aliquam quantitatem specificam vendere, sed aget ut agens venditio nostra utens ad commercium rationabiles conatus consentaneum cum suis exercitiis mercaturae et venditionibus normalibus. Nulla ordinatio pro pecunia recipienda in aliqua fiduciari, fide vel simili compositione.

Agentia distributio communi commissioni aequabitur ad 3.5% de pretio venditionis crassae in partem venditam. In nexu cum venditione partium communium pro nobis, singula agentium Distributionis censentur esse "scriptor" in sensu Securitatum Actus et recompensatio Distributionis agentium commissiones seu infringationes subscriptores censentur. Constat etiam nobis indemnificationem et contributionem agentibus Distributionibus providere respectu quorundam onerum, inclusis onerum sub actu securitatis.

Ourcommon stock is listed on The Nasdaq Capital Market under the symbol “GHSI.” January 20, 2022, the last reported sale priceof our common stock on The Nasdaq Capital Market was $0.55 per share.

Investingin communis stirpis pericula involvit. Vide "Periculum Factors" incipientes a pagina S-6 huius supplementi prospecti ac periculorum et dubiorum descriptorum in documentis limamus cum Securitatibus et Commissione Exchange quae inseruntur huic prospectussupplimento referendo pro quibusdam periculis et incertis ad obsidendum in nostro communis stirps.

Nec Securitates et Commercium Commercium, nec Securitates aliquae Status Commissio, nec aliqua alia Corpus moderatorium has securitates approbavit vel improbavit, vel super adaequationem vel accurationem prospecti huius supplementi vel Prospecti comitantis. Contrarium est quaelibet repraesentatio criminalis.

Thisprospectus supplement is dated 28 Ianuarii 2022 a.

TABLEOF CONTENTS

ProspectusSupplement

Prospectus

Nolumus, ac Distributio Agentia non habemus, auctoritate quisquam tibi praebere informationem diversam ab eo quod continetur vel incorporatum est in hoc prospecto supplemento, prospectus comitatus vel ullius scripturae gratis prospectus praeparamus vel auctorizamus, nec nos nec agentium distributio quicquam accipimus. responsabilitas pro quibusvis aliis informationibus quas alii tibi dare possunt. Haec prospectus supplementis oblatio non est vendendi, nec petitio oblationis ad emendum praedes alicuius iurisdictionis, ubi oblatio vel venditio non permittitur. Non debes fingere informationes in hoc supplemento prospectus contineri, prospectus comitans, vel prospectus alicuius gratis scripto accuratus esse sicut cuiuslibet diei praeter tempus in antepagmento illorum documentorum, vel informationes contentas in aliquo documento a relatione insertas esse. accurate ut de quolibet moderno praeter tempus documenti, quo referat incorporatum, pro tempore traditionis prospectus huius supplementi vel cuiuslibet venditionis nostrarum praedes. Negotium nostrum, conditio nummaria, eventus operationum et exspectationum post dies illos mutari possunt.

DE PROSPECTUS SUPPLEMENT

Thisprospectus supplement and the accompanying prospectus relate to the offering of our common stock. Before buying any of the common stockthat we are offering, you should carefully read this prospectus supplement, the accompanying prospectus, the information and documentsincorporated herein by reference and the additional information under the heading “Where You Can Find More Information” and“Incorporation of Documents by Reference.” These documents contain important information that you should consider when makingyour investment decision.

Thisprospectus supplementum et prospectus comitans partem adnotationem constitutionis de Forma S-3 (Fili No. 333-248895) quae cum Securitatibus et Commisio Commerciorum delineavit, vel SEC, et efficax declaratum est a SEC die 24 Septembris 2020 Sub hac adnotatione processus, communi stirpe de tempore in tempore offerre possumus, praelata stirpe, pignoribus debitum, ferat, iura et unitates, quorum haec oblatio pars est.

Thisdocument is in two parts. Prima pars est haec prospectus supplementum, quod condiciones oblationis communis stirpis describit atque etiam addit, updates et mutationes informationes quae in comitatu prospecti ac documentis incorporantur per comparationem. Secunda pars est comitatus prospectus, quae magis generalia praebet. informationem de communi stirpe nostra et aliis pignoribus, que ad hanc oblationem communis stirpis non pertinent. Si informationes huius prospecti supplementi a prospecto comitante abhorret, informationes in hoc supplemento prospecti inniti debetis. Quatenus conflictus inter informationes quae in hac prospecti supplemento continentur, una ex parte, et notitiae quae in aliquo documento, quod in hac prospectussupplement incorporatur, ex altera parte, notitia huius prospecti supplementi inniti debetis. Si quis enuntiatio in uno ex his documentis abhorret a constitutione in alio documento post tempus habente, exempli gratia, documentum insertum referente in hunc prospectum supplementum — enuntiatio in documento posteriori temporis modificando vel superat priori enuntiatione.

Youshould rely only on the information contained in, or incorporated by reference into this prospectus supplement and in any free writingprospectus that we may authorize for use in connection with this offering. We have not, and the Distribution Agents have not, authorizedany other person to provide you with different information. If anyone provides you with different or inconsistent information, you shouldnot rely on it. We are not, and the Distribution Agents are not, making an offer to sell or soliciting an offer to buy our securitiesin any jurisdiction in which an offer or solicitation is not authorized or in which the person making that offer or solicitation is notqualified to do so or to anyone to whom it is unlawful to make an offer or solicitation. You should assume that the information appearingin this prospectus supplement, the documents incorporated by reference into this prospectus supplement, and in any free writing prospectusthat we may authorize for use in connection with this offering, is accurate only as of the date of those respective documents. Our business,financial condition, results of operations and prospects may have changed since those dates. You should read this prospectus supplement,the documents incorporated by reference into this prospectus supplement, and any free writing prospectus that we may authorize for usein connection with this offering, in their entirety before making an investment decision. You should also read and consider the informationin the documents to which we have referred you in the sections of this prospectus supplement entitled “Where You Can Find MoreInformation” and “Incorporation of Documents by Reference.”

Munera vendendi, et quaerunt offert emere, portiones communis stirpis tantum in jurisdictionibus ubi offert et venditio permittitur. Prospectus huius supplementi distributio et oblatio communis stirpis in aliquibus iurisdictionibus iure restringi possunt. Extra Civitatum Foederatarum, qui huius supplementi prospectus in possessionem veniunt, certiores se facere debent et observare restrictiones quae ad oblationem communis generis et distributionem prospecti supplementi extra Civitates Foederatae sunt. Hoc prospectussupplementum non constituit, nec adhiberi potest circa, oblatum ad vendendum, vel sollicitationem oblatum ad emendum, cuiuslibet fideiussores per hanc prospectum supplementum a quavis persona oblatum est, in qua non licet ei dare. talem offerentem rogationem faciunt.

References in hoc prospecto supplemento "Custodes," "nos," "nos", "nostrae," "nostrae," seu "Societas" est custodia Scientiarum Medicae, Inc., corporatio Delaware, eiusque subsidiaria solidata, nisi occidens. aliter vel aliter indicat contextus.

CAUTIONARYNOTE REGARDING FORWARD-LOOKING STATEMENTS

Thisprospectus supplementum et prospectus comitantium, inter documenta, quae referendo incorporamus, enuntiationes deinceps continent intra sensum sectionis 27A Securitatum Actus et Sectio 21E Securitatum Actus Commutationis 1934, ut emendata (per "Act Commutatio") . Quaecumque propositiones in hoc prospecto et quolibet comite prospectum supplementum circa exspectationes nostras, opiniones, consilia vel intentiones circa productum progressionem et mercaturam nostram nisus, investigatio et progressus nisus, negotiatio, conditio pecuniaria, eventus operationum, consilia aut prospectus, aliaque similia. non historica et deinceps-lookstatements. Hae propositiones saepe, sed non semper, verbis vel phrasibus adhibitis, ut "credere," "voluntare," sperare, "antcipare," "aestimare," "intendere," "consilium" et "vellere". "Exempli gratia, constitutiones de conditione oeconomica, possibilis vel assumpta futuros operationum eventus, occasiones augendi, industriae ordinem, consilia et proposita administrationis, mercatus communis nostrae stirpis ac futurae administrationis ac structurae normae sunt omnes propositiones prospectantes. Prospectus propositiones non sunt cautiones perficiendi. Involvunt notas et ignotas pericula, incerta et suppositiones quae eventus actuales efficere possunt, gradus agendi, agendi vel res gestae materialiter ab omnibus eventibus differre, gradus actionis, actionis, actionis, gestorum, quavis propositione deinceps expressa vel implicata.

Quaecumque propositiones prospectus in universum sunt habiles sunt secundum factores periculorum, de quibus in toto hoc prospecto supplemento et prospectus comitante. Quaedam periculorum, dubiorum et suppositionum quae causare eventus actuales possunt materialiter ab aestimationes vel proiectiones differre, quae in propositionibus anterioribus spectantibus comprehenduntur, sed non limitantur ad;

Praecedentis index nonnulla proponit, sed non omnia, factorum quae facultatem nostram attingere possent ad consequi eventus, de quibus in aliqua deinceps prospicientia descriptos. Prospectum hoc supplementum et comitatus prospectus ac documenta quae huc illuc referimus ac documenta proposita in adnotatione adfirmare debes, cuius prospectus hic pars est, plane et intellegens quod eventus futuri nostri materialiter differant ab illis quae non expecto. Pone informationes quae in hoc prospecto supplemento, prospectus comitante, et quodlibet futuri supplementi prospecti comitante solum accuratum esse, sicut ante tempus diei huius supplementi prospectus vel prospectus talis comitatus. Quia factores periculi de quibus in paginis 8-10 huius supplementi prospecti 5 Prospectus comitatus et per respectum incorporatus, eventus vel eventus posset materialiter differre ab iis qui per nos vel pro nobis expressis perspectis constitutionibus, nullis deinceps propositis indebite confideres. Praeterea, quaelibet propositio prospicienti solum loquitur de tempore quo fit, et, praeterquam iure praecepto, nullam obligationem suscipimus prospiciendi propositio ad res gestas vel circumstantias, post tempus, quo enuntiatur. eventum seu praeventus reflectere. Novae factores subinde emergunt, neque possibile est nos praedicere quae res oriantur. Praeterea, ictum uniuscuiusque factoris in negotiatori nostro aestimare non possumus quantum ad quemlibet factorem, vel concursum factorum, efficere potest ut eventus materialiter ab iis, quae in prospectu dicta sunt, differant. Omnes informationes in hoc prospecto supplemento et prospectus comitante, ac praesertim propositiones promptas, his cautionibus.

PROSPECTUSSUPPLEMENT BREVIARIUM

Thissummary highlights selected information about us, this offering and selected information appearing elsewhere in this prospectus supplement,the accompanying prospectus, and in the documents we incorporate by reference herein and therein. This summary is not complete and doesnot contain all of the information that you should consider before deciding whether to invest in our common stock. You should read thisentire prospectus supplement, and the accompanying prospectus, carefully, including the “Risk Factors” section beginningon page S-6 of this prospectus supplement, the “Risk Factors” section of our most recent Annual Report on Form 10-K, asmay be amended, supplemented or superseded from time to time by other reports we file with the SEC, and our financial statements andthe related notes and the other documents incorporated by reference in this prospectus supplement.

Overview

Societas clinica nutritionis et diagnostica utatur quae fovetur et distribuit nutritionem, cibum medicinae, supplementa medicamina. Portfolio offert scientiarum fundatorum, amet sustineri productos et machinis destinatos ad curationem promissionum et provisorum, eorumque aegros et consumers.

Wesee opportunities to grow our business and create value by acquiring, developing and distributing condition-specific, clinically provennutrition, medical foods, supplements and diagnostic devices. Our portfolio of science-based, clinically supported products support healthcareprofessionals, their patients, and consumers in achieving health goals.

Ourprofile et focus fundamentaliter mutatur cum acquisitione nutritionis Activalis, LLC ("Activ") mense Iunio 2021, possessor et distributor lineae supplementorum ad valetudinis ossis, salutis immunis et aliis applicationibus.

Theacquisitio et integratio linearum viactivorum productorum nostram positionem oeconomicam, forum profile ac focus notam mutavit, et etiam inquisitionem nostram amplificavit ad ulteriores occasiones negotiorum in brevi termino tam interno quam externo.

Webelieve the Activ acquisition adds valuable attributes, including (1) Viactiv’s brand awareness and acceptance from the consumer;(2) experienced management; (3) established distribution networks and relationships; (4) product development potential; and (5) a longtrack record of revenue growth and profitability.

Acquisitionof Activa Nutritionis

OnJune 1, 2021, we completed our acquisition of Activ. The acquisition was made pursuant to an Equity Purchase Agreement dated May 18,2021, between us, Adare and Activ. We acquired all of the issued and outstanding equity of Activ from Adare for $26 million in cash,subject to certain adjustments as provided in the Equity Purchase Agreement.

Activowns linea supplementi Viactiv ruminat pro sanitate, immune sanitate et aliis applicationibus, quae nunc per plures venditores nationis maximae venales sunt, inter alios, Walmart (retail and online), Target and Amazon. Productilia viactivorum lineae uberrimae nostrae erunt pro praevisa futura absentia quaevis adquisitiones significantes additis.

RecentDevelopments

NasdaqNotification of Failure to Satisfy a Continued Listing Rule or Standard

Die 25 Ianuarii 2022 notificationem accipimus ex Nasdaq relatas ad defectum nostrae pretium minimum pretium $ $1 per participes conservandi. Substructio pretii clausurae pro ultimis XXX diebus continuos negotiorum, Societas hanc postulationem non amplius convenit. Nihilominus, Regulae NasdaqListing etiam Societati obsequia praebent periodum 180 dierum calendarii quibus obsequia repetuntur. Proinde, si quando a die huius notificationis usque ad diem 25 Iulii 2022, clausura pretium communis stirpis nostrae pretium $1 minimum decem continuos dies, Nasdaq nobis praebebit confirmationem obsequii et res erit. clauditur.

VectorVisionRestructuring

DuringDecember 2021, as part of management’s comprehensive evaluation of the Company’s business in order to focus on those brandsand lines of business that management believes provide the greatest growth opportunities, the Company determined to restructure the operationsof the Company’s VectorVision medical device business. The Company is in the process of substantially winding down the day-to-dayoperations of VectorVision, which is expected to significantly reduce costs, and to instead explore various alternative ways to preserve,manage and exploit the Company’s various related intellectual property rights, including its patents, associated with the VectorVisiontechnology, which rights the Company believes are valuable and marketable. The Company is exploring both domestic and international businessopportunities, such as licensing and distribution arrangements, with experienced parties, which could assist the Company in the economicexploitation of these intellectual property rights. As a result of this change to the VectorVision business strategy, management believesthat it will be able to better focus its efforts and deploy capital to more growth oriented brands and product lines, like Viactiv, andother products in development, that it hopes to expeditiously bring to market in 2022.

NasdaqCompliance

Stirps nostra communis negotiatio infra $1.00 die X Decembris 2021 negotiari incipiunt et infra $1.00 omnem mercaturam diem clausit. Praecepta currentis seriei Nasdaq continebant minimum pretium pretium saltem $1.00 require; si pretium stipes iussa claudit infra $1.00 per spatium negotiorum 30 continuorum dierum, deficiens consideratur et notificationem a Nasdaq accipiet. Societas ergo 180 calendaria habet ab intimatione ad obsequium reducendum servando $1.00 pretium claudendi pretium minimum decem continuos dies negotiorum consecutivorum inter 180-die tempus obsequium. Societates in Foro Capitali Nasdaq inscriptae vel transferendae possunt esse eligibile secundum tempus 180 calendarii ad obsequium recuperandum si quaedam requiruntur occurrant, quae provenire possunt in summa obsequio tempus ad sanandum pretium pretium defectus usque ad 360 dies fastos. Proinde, si stirps nostra infra $1.00 usque ad diem 24 Ianuarii 2022 mercari pergit, notificationem non-obsequium a Nasdaq recipiemus, si obsequium supra tempus non recuperare debeamus, communis stirps nostra a Nasdaq todelisting erit.

SupplyChain Constraints

Copiam catenae angustiae per COVID-19 pandemicam experti sumus. Hae angustiae mense Decembri anni 2021 inceperunt et continuaverunt anno 2022. Hae angustiae facultatem nostram impingebant ad inventarium obtinendum ad notam emptoris implendam pro nostra notam viactiv et perseveret incidat facultatem nostram ad implendos ordines mos progressus.

CorporateInformation

Ourmailing address is 2925 Richmond Avenue, Suite 1200, Houston, TX 77098. Our telephone number is (800) 873-5141 and our website addressis www.guardionhealth.com. The information on our website is not part of, and should not be construed as being incorporated byreference into, this prospectus supplement and the accompanying prospectus.

THEOFERING

(1)Based on 24,426,993 shares of common stock outstanding as of January 28, 2022 and excludes:

RISKFACTORS

Aninvestment in our common stock involves a high degree of risk. Prior to making a decision about investing in our common stock, you shouldcarefully consider the risk factors described below and the risk factors discussed in the sections entitled “Risk Factors”contained in our most recent Annual Report on Form 10-K, as may be amended, supplemented or superseded from time to time by other reportswe file with the SEC and incorporated by reference in this prospectus supplement, together with all of the other information containedin this prospectus supplement and the accompanying prospectus. Additional risks and uncertainties not presently known to us, or thatwe currently view as immaterial, may also impair our business. If any of the risks or uncertainties described in our SEC filings or thisprospectus supplement and the accompanying prospectus or any additional risks and uncertainties actually occur, our business, financialcondition and results of operations could be materially and adversely affected. In that case, the trading price of our common stock coulddecline and you might lose all or part of your investment.

RisksRelated ad acquisitionem Nutritionis Activ

Negotium integrating activum cum negotiis nostris difficilius, pretiosus, temporis consumptio quam expectatio esse potest, et utilitates expectatas acquirendi Activ, quae adversatur nostris negotiis, condicionibus et eventibus operationum, non possumus cognoscere.

Ifwe experience greater than anticipated costs to integrate, or are not able to successfully integrate, Activ’s business into ouroperations, we may not be able to achieve the anticipated benefits of our acquisition of Activ, including cost savings and other synergiesand growth opportunities. Even if the integration of Activ’s business is successful, we may not realize all of the anticipatedbenefits of our acquisition of Activ during the anticipated time frame, or at all. For example, events outside our control, such as changesin regulations and laws, as well as economic trends, including as a result of the COVID-19 pandemic, could adversely affect our abilityto realize the expected benefits from our acquisition of Activ. An inability to realize the full extent of the anticipated benefits ofour acquisition of Activ could have an adverse effect upon our revenue, level of expenses, and results of operations.

Activmay onera quae nobis non nota sunt.

Activmay onera, quae nos defecerunt, vel non potuimus, invenire in cursu nostro debitae diligentiae inquisitiones in nexu cum Activ acquirendo. Adde informationes de Activ, quod materialiter et adversatur nos et activum, sicut incognita vel contingentia onera et onera pertinentia ad obsequium cum legibus applicabilibus. Praeterea, Activ subesse potest auditionibus, recognitionibus, inquisitionibus, inquisitionibus et petitionibus non-obsequiae et litis per foederati et statui moderatrices institutionum quae in oneribus vel aliis sanctionibus provenire potuerunt. Quaelibet huiusmodi onera vel sanctiones, sive singuli sive in universitate, adversam effectum habere possunt in negotiis nostris, condicionibus oeconomicis et eventuum operationum.

Wehave made certain assumptions relating to the Activ acquisition that may prove to be materially inaccurate.

Quaedam suppositiones ad acquisitionem activum pertinentes, quae impropria esse possunt, inclusa ex defectione percipere sperata beneficia Activorum acquisitionis, defectus ad speranda vectigalium incrementa percipienda, altiora quam expectata operae et mercaturae impensae, ac etiam condiciones oeconomicae et negotia generales quae nostro Societati adversatur.

RisksRelated huic oblatio

Ourmanagement will have broad discretion over the use of the net proceeds from this offering, you may not agree with how we use the proceeds,and the proceeds may not be invested successfully.

Nostrae administrationis ampla erit discretio quoad usum retis ex quacunque oblatione a nobis procedens et iis uti potest ad usus praeter eos qui tempore oblationis huius spectati sunt. Ideoque fretus eris iudicio nostrae administrationis quoad usum harum retia procedens, et non habebis facultatem, prout in parte constituendi deliberandi, perpendendi an recte procedendum sit. Fieri potest ut proventuum investiatur via quae non cedit pro nobis vel aliquo commodato.

Youmay experiris solutionem immediatam et substantialem in rete libri tangibili valoris per participationem communis stirpis, quam in oblatione acquiras.

Theoffering price per share in this offering may exceed the pro forma net tangible book value per share of our common stock outstandingprior to this offering. Assuming that an aggregate of 45,454,545 shares of our common stock are sold at a price of $0.55 per share, thelast reported sale price of our common stock on The Nasdaq Capital Market on January 20, 2022 for aggregate gross proceeds of $25,000,000,and after deducting commissions and estimated aggregate offering expenses payable by us, you will experience immediate dilution of $0.02per share, representing the difference between our pro forma net tangible book value per share, as adjusted, as of September 30, 2021after giving effect to this offering and the assumed offering price. The exercise of outstanding stock options or warrants could resultin further dilution of your investment. See the section below entitled “Dilution” for a more detailed illustration of thedilution you would incur if you participate in this offering.

Youmay experiri futuram dilutionem ex aequitate futurae oblationes.

Ut additamenta capitalia tollamus, in posterum alias portiones communis stirpis nostrae vel alias cautiones additas convertibiles intoor commutabiles pro communi stipite pretia nostra non eadem sint ac pretia huius oblationis participes. Partes vel alias cautiones vendere possumus in alia oblatione pretio in portione minore quam per partem quam ab aliquo in hac oblatione persoluta, et investitores emendi portiones vel alias cautiones in futuro iure potiores habere possunt cum cauponibus existentibus. Pretium pershare quo alias partes communis stirpis nostrae vendimus, vel cautiones in commune convertuntur vel commutabiles, in futuris transactionibus altior vel minor esse potest quam pretium pro portione a quibusvis obsidibus in hac oblatione persolvi.

Salesof a substantial number of our shares of common stock in the public markets, or the perception that such sales could occur, could causeour stock price to fall.

Wemay proventus et vendere additas partes communis stirpis in mercatu publico, etiam in hac oblatione. Quam ob rem, numerus substantialis communis stirpis nostrae in foro publico vendi potest. Venditio substantialis numerus partium communium in mercatis publicis, incluso in hac oblatione, seu perceptio talis venditio fieri potuit, annonam communis stirpis deprimere potuit et facultatem nostram capitalem per venditionem additi aequitatis imminuere. pignori.

Quia nunc in praevisis futuris communis stirpis dividendis nummis declarare non intendimus, venditores aestimare debent valorem communis stirpis pro quolibet reditu in obsidendo.

Wehave never paid cash dividends on our common stock and do not plan to pay any cash dividends in the near future. We currently intendto retain all of our future earnings, if any, to finance the operation, development and growth of our business. Furthermore, any futuredebt agreements may also preclude us from paying or place restrictions on our ability to pay dividends. As a result, capital appreciation,if any, of our common stock will be your sole source of gain with respect to your investment for the foreseeable future.

Theexercitatio praestantium optionum et cautionum cauponarum extenuabit ac deminuto pretio nostro potuit.

Theexercitatio praestantium optionum et cautionum nostrae stirpis pretium adversare potest ob venditiones plurium partium seu theperceptionum quae tales venditiones fieri possunt. Quae res etiam difficiliorem reddere potuerunt pecunias per futuras oblationes nostrarum cautionum, et condiciones adversas infringere, quibus etiam aequitas capitalis consequi potuimus. Exercitatio praestantium optionum et cautionum seu quaevis futurae editae accessiones partium communis stirpis vel aliarum cautionum, inclusis, sed non limitata ad praeferendas rationes, optiones, warantizationes, unitatum stirpis restrictae vel aliae securitates derivatae in communem stirpem nostram converti possunt, inveniatur in significantdilutione ad nostram stockholders et minui potest nostra stirpe pretio.

Thecommon stock offered hereby will be sold in an “at the market offering”, and investors who buy shares at different timeswill likely pay different prices.

Investors qui mercantur partes huiusmodi oblationis diversis temporibus verisimiliter alia pretia reddent, et ideo diversos eventus in obsidendi eventibus experiri possunt. Discretionem habebimus, sub mercatu postulato, variare sincere, pretia, numerosque portionum venditarum, nec est pretium minimum vel maximum venditio. Obsidores declinationem experiri possunt in valore portionum suarum propter portiones factas pretia minora quam pretia quae solverant.

Actualis numerus participatorum sub Pacto Sales, quovis tempore vel toto, incertus est.

Subjectto certain limitations in the Sales Agreement and compliance with applicable law, we have the discretion to deliver a sales notice toeither of the Distribution Agents at any time throughout the term of the Sales Agreement. The number of shares that are sold by a DistributionAgent after delivering a sales notice will fluctuate based on the market price of the common stock during the sales period and limitswe set with the Distribution Agent. Because the price per share of each share sold will fluctuate based on the market price of our commonstock during the sales period, it is not possible at this stage to predict the number of shares that will be ultimately issued by us.

RisksRelated to our Securities and our Business

Notificatio a Nasdaq notificata non sumus nos in obsequio illorum requisitorum continuarum recensentium ob clausuram pretii nostri communis stirpis per proximos XXX dies continuos. Defectum ad obsequium recuperandum provenire potuit in securitate nostra aNasdaq deleta quae materialem effectum adversam in negotiis nostris et operationum eventuum habere potuerunt.

NasdaqNotification of Failure to Satisfy a Continued Listing Rule or Standard

Die 25 Ianuarii 2022 notificationem accipimus ex Nasdaq relatas ad defectum nostrae pretium minimum pretium $ $1 per participes conservandi. Substructio pretii clausurae pro ultimis XXX diebus continuos negotiorum, Societas hanc postulationem non amplius convenit. Nihilominus, Regulae NasdaqListing etiam Societati obsequia praebent periodum 180 dierum calendarii quibus obsequia repetuntur. Proinde, si quando a die huius notificationis usque ad diem 25 Iulii 2022, clausura pretium communis stirpis nostrae pretium $1 minimum decem continuos dies, Nasdaq nobis praebebit confirmationem obsequii et res erit. clauditur. Societates in Foro Capitali Nasdaq inscriptae vel transferendae possunt eligi secundum tempus CLXXX calendarii temporis ad obsequia repetenda, si quaedam requiruntur occurrant, quae provenire possunt in summa obsequii periodo ad sanandum pretium pretium defectus usque ad 360 dies fastos. Si non defuerimus obsequia periodi quae supra referuntur, communis stirps nostra subiicietur a Nasdaq delitescens, quae materialem adversam effectionem negotiorum et eventuum operationum habere potuit.

Copiam catenae coactionis experti sumus propter COVID-19 pandemiam quae negotium nostrum impactum fuerat. Si ab his angustiis tolli pergimus, materialem effectum in negotiis nostris et operationum eventibus adversam habere potuit.

Wehave been experiencing supply chain constraints due to the COVID-19 pandemic. These constraints began in December 2021 and have continuedinto 2022. These constraints have impacted our ability to obtain inventory to fulfill customer orders for our Viactiv brand and may continueto impact our ability to fulfill customer orders going forward which would have a material adverse effect on our business and resultsof operations.

USEOF PROCESSIBUS

Wemay proventus et partes venditionis communis stirpis habentis aggregati venditiones crassas procedunt usque ad $25,000.000 subinde. Quia nulla minima oblatio requiritur ut conditio ad hanc oblationem claudendam, ipsa oblatio publica totalis moles, commissiones ac si quae nobis procedunt, hoc tempore determinatae non sunt.

Weintend to use the net proceeds from this offering for general corporate purposes. We may also use the net proceeds to expand the marketingof our existing products, to develop additional products, and/or invest in or acquire complementary businesses, products, or technologies,although we have no current commitments or agreements with respect to any such investments or acquisitions as of the date of this prospectussupplement. We have not determined the amount of net proceeds to be used specifically for the foregoing purposes or any others we maypursue. As a result, our management will have broad discretion in the use and allocation of the net proceeds and investors will be relyingon the judgment of our management regarding the application of the net proceeds from any sale of the securities. Pending use of the netproceeds, we currently intend to initially invest the proceeds in short-term, investment-grade, interest-bearing instruments and/or securities.

TEMPUS

Si in hac oblatione collocaveris, interest dominii tui dilutum quantum intersit inter gratuitam oblationem publici portionis ac retia valoris libri tangibilis adaequatum per participes, postquam effectum dedit huic oblationi.

Wecalculate net tangible book value per share by dividing the net tangible book value, which is tangible assets less total liabilities,by the number of outstanding shares of our common stock. Dilution represents the difference between the amount per share paid by purchasersof shares in this offering and the as-adjusted net tangible book value per share of our common stock immediately after giving effectto this offering. Our net tangible book value as of September 30, 2021 was approximately $13,196,582, or $0.54 per share of common stock.

Effectus post acceptionem venditioni 45,454,545 portionum communis stirpis nostrae iuxta prospectum huius supplementi et comitatus prospectusin universitatis quantitatem $25,000,000 cum assumpta oblatione pretium $0,55 per participes, novissime nuntiavit pretium venditionis communis nostri Stockon The Nasdaq Capital Market on. Die 20 Ianuarii 2022, deductis commissionibus et estimatis aggregatum oblationis expensas solvendas per nos, nostri libri valoris rete adaequati quantum ad diem 30 Septembris 2021 circa $37,051,582, vel $0.53 pershare communis stirpis fuisset. Hoc repraesentat immediatum incrementum in rete libri tangibili valoris ex $0.01 per partem nostro existentem stockholder et immediatam dilutionem in rete libri tangibili valoris $0,02 per participes ad novos collocatores.

Mensa sequentia hanc dilutionem in per participationem fundamenti illustrat:

Thetable supra supponit pro propositis illustrandis quod aggregatum ex 45,454,545 portiones communis nostrae stirpis venditae sunt iuxta prospectussupplement et comitatus prospectus pretio $0.55 per participes, novissime nuntiavit pretium venditionis communis generis in Foro NasdaqCapital die 20 mensis Ianuarii. , 2022, pro aggregato crassa proventuum $25,000,000. Portiones in hac oblatione, si qua fuerint, vendantur subinde variis pretiis. Augmentum $0,08 per participationem pretii quo partes venditae sunt ex assumpti precii $0,55 per portionem in mensa supra ostensa, si omnis generis communis nostri in aggregato quantitatis $25,000,000 eo pretio venditur, eveniret. ut adaequatum rete libri tangibile valorem per participes post oblationem $0.58 per participes et augeret dilutionem in rete libri tangibili pretii per participes novis investors in hac oblatione ad $0.04 per participes, deductis commissionibus et estimatis aggregatum oblationis expensas a nobis solvendas. Deminutio $0.25 pro portione quantitatis, quo partes venditae a thesumptione oblationis precii $0,55 per portionem in mensa supra ostensa sunt, si omnia communis stirpis nostrae in aggregato quantitatis $25,000,000is emptae eo pretio evenirent. quasi adaequatum rete libri tangibile valorem per participes post oblationem $0.34 per portionem ac dilutionem in rete libri tangibili valore per participationem novis obsidibus in hac oblatione ad $0.20 per portionem deductis, depositis commissionibus ac aggregatum oblationis expensis nobis solvendis aestimatum.

Disceptatio et tabula supra scripta die 24,426, 993 participatio communis stirpis nostrae praestantes ut 30 septembris 2021 innituntur et sequentes excludit omnes ut 30 septembris 2021;

Quatenus optiones vel cautiones exercentur vel alias securitates derivativas exercentur vel convertuntur in communes, adhuc adhuc diluuntur novis obsidibus.

PLANOF DISTRIBUTIO

Wehave entered into the Sales Agreement with Maxim and Roth, collectively as the Distribution Agents, dated January 28, 2022, underwhich we may issue and sell shares of our common stock from time to time through either of the Distribution Agents, at our discretion,subject to certain limitations, pursuant to this prospectus supplement and the accompanying prospectus. As of the date of this prospectussupplement, we have issued and sold an aggregate of 7,608,674 shares of our common stock for aggregate gross proceeds of approximately$35,000,000 and net proceeds of approximately $33,950,000 pursuant to the January 2021 Sales Agreement (as defined herein) in the January2021 and February 2021 “at the market offerings”.

Salesof usque ad $25,000,000 portionum communis stirpis nostrae, si quae sub hoc prospecto supplemento in venditionibus fieri possunt, censenda est "at fori oblatio" prout definita est in Regula 415 promulgata sub Securitatibus Act. Si nos et Agentes Distributiones consentiunt de quolibet modo distributionis praeter venditiones portionum communis stirpis nostrae in Forum Capital Nasdaq vel mercaturae mercaturae in Civitatibus Foederatis existentibus in annona mercati, ulteriorem prospectum supplementum ad omnia informationes de tali oblatione providebimus. a Regula 424 (b) sub Securitatibus Act. Distributio agentium instituimus ne communi nostro vendant, si venditio fieri non possit vel supra pretium a nobis in tempus designatum. Nos vel procuratores distributionis oblationem communitatis nostrae in notitiam et alias condiciones subiectas suspendimus.

Sub condicione Sales Agreement, nullo eventu Societas exibit vel vendet per Distributionem Agentia talem numerum vel pupa quantitatem portionum communis stirpis quae (i) numerum vel pupa portionum communis stirpis descripserunt et praesto in Registratione excedunt. Declaratio (ii) numerum auctoritatum excedunt, sed non esuetatae partes communis stirpis (iii) excedunt numerum vel dollar quantitatem portionum Communis Stock permissi vendendi sub Forma S-3 (including Instructionem generalem I.B.6 eius, si adhibetur) vel (iv) numerum vel dollarorum communis stirpis quantitatem excedant, pro quo Societas prospectum supplementum ad Registration Statement interposuit.

Eachtime we wish to issue and sell common stock under the Sales Agreement, we will notify one of the Distribution Agents, at our discretion,of the number of shares to be issued, the dates on which such sales are anticipated to be made, any minimum price below which sales maynot be made and other sales parameters as we deem appropriate. Once we have so instructed a Distribution Agent, unless the DistributionAgent declines to accept the terms of the notice, such Distribution Agent has agreed to use its commercially reasonable efforts consistentwith its normal trading and sales practices to sell such shares up to the amount specified on such terms. The obligations of the DistributionAgents under the Sales Agreement to sell our common stock are subject to a number of conditions that we must satisfy. Further, underno circumstances will we deliver a transaction notice to both Distribution Agents concurrently.

Distributionem Agentes commissiones pro suis officiis in agendis procuratoribus in venditione communis stirpis nostrae reddemus. Distributiones distributio communi commissioni aequabitur ad 3.5% de pretio venditionis crassae in partem venditam. Quia nulla minima oblatio requiritur ut condicio ad hanc oblationem claudendam, ipsa oblatio publica totalis quantitatis, commissionum, ac commissionum nobis, siany hoc tempore procedit, non sunt determinatae. Praeterea divisionem Agentia taxarum et erogationum ad suum consilium legale pertinentia in quantitate non $60,000 excedere convenit, reddere. Distributionem agentium de mercedibus et erogationibus ad suum consilium legale pro unaquaque quarterio retractandis constat, pro qua deductio requiritur moles non excedere $3,500. Aestimamus impensas thetas pro oblatione, excepta recompensatione solvendarum agentibus distributionis sub terminis pacti Sales, circiter $210,000 futurum esse.

Settlementfor venditio communis stirpis nostrae occurret in secundo negotio post diem, quo aliqua venditio fiunt, vel in tali tempore, qualis tunc industria usus est ad negotiationem regularem, vel in alio quovis tempore quod a nobis et a nobis convenitur. applicabilis DistributionAgent in nexu cum transactione particulari, in reditu ad solutionem retis nobis procedit. Nulla ordinatio pro fundsto recipiatur in escrow, fide vel simili compositione.

Inconnection with the sale of the common stock on our behalf, each of the Distribution Agents will be deemed to be an “underwriter”within the meaning of the Securities Act, and the compensation of the Distribution Agents will be deemed to be underwriting commissionsor discounts. We have agreed to provide indemnification and contribution to the Distribution Agents against certain civil liabilities,including liabilities under the Securities Act.

Oblatio, juxta Venditio Agreement, finem terminabit in antecessum (i) issuance and sale of all shares of our stock subject to Sales Agreement, or (ii) termination of Sales Agreement sicut in eo permittitur.

Maximus ius primae recusationis per XII mensium periodum a die ultimae venditionis participum communis stirpis secundum tenorem pacti Sales datis die 8 mensis Ianuarii anno 2021 ac inter nos et Maximum (die "Ianuarii 2021 pactum venditionis ”), agere in libro procuratoris currentis, subscriptorem ducere et/vel procurationem ducere pro quacumque aequitate publica vel privata, aequitate coniunctorum debitorum (exclusis debitis mercatorum argentariis) oblationes in tali tempore XII mensis. Mensis XII, quae periodus in effectu manet usque ad diem X mensis Februarii, anno MMXXII, nec vi aliqua venditio sub hoc pacto venditionis extendetur. Societas nullum aliud ius primae recusationis praebuit partem in foro cuiusvis partis oblationis.

Thissummary of the material provisions of the Sales Agreement does not purport to be a complete statement of its terms and conditions. Acopy of the Sales Agreement was filed with the SEC as an exhibit to a Current Report on Form 8-K filed on January 28, 2022. See“Where You Can Find More Information” below.

Agentes distributiones eorumque affiliates in posterum praebere possunt varias collocationes faenus et alia officia pecuniaria pro nobis et nostris Sociis, pro quibus servitiis in futurum recipiant feoda consueta. Quatenus per regulam M requirit, Distributiones Agentes in mercatu faciendo vel stabiliendo non exercebunt actiones quas communes nostras implicant, dum oblatio permanentis sub hoc supplemento prospecti et comitatus prospectus. Maxim subscriptorem egit pro oblatione securitatium publicarum, quae mense Octobri 2019 et Augusto 2019 consummatae erant, eisque Maxim commissiones $670,320 et $467, 200, respective accepit. Maxim etiam egit ut sola distributio agentis in nexu cum nostro Ianuario et Februario 2021 "in foro" oblationes sub pacti Sales conventionis, secundum quas Maxim commissiones aggregatas accepit de $1,050,000.

LEGALMATTERS

Sheppard,Mullin, Richter & Hampton LLP, Los Angeles, California, has passed upon the validity of the common stock offered hereby. EllenoffGrossman & Schole LLP, New York, New York, is counsel for the Distribution Agents in connection with this offering.

PERITIS

Weinberg& Societas, P.A., independentes ratiunculam publicam firmam descripserunt, audiverunt constitutiones nostras nummarias contexuisse sicut Decembris 31, 2020 et 2019, et annis tunc finitis, sicut in relatione eorum exposita, quae in hac prospectussupplement et relatione incorporatum est. comitante prospectus. Nostrae constitutiones nummariae incorporatae sunt per relationem de Weinberg & Company, P.A. relatio, quae periti in ratione et audiendo auctoritate sua data sunt.

WHEREYOU CAN FIND MORE INFORMATION

Subiecti sunt relationibus requisitis Exchange Actus et fasciculi annuis, quattuor et currentibus relationibus, procuratoribus constitutionibus et aliis informationibus cum SEC. Nostrae tabulationes SEC etiam in pagina SEC in www.sec.gov praesto sunt.

Thisprospectus supplementum et prospectus comitans partem praebent adnotationee constitutionis de Forma S-3 quae a nobis proposita est cum SEC underthe Securities Act. Sicut per SEC permissum est, hoc supplementum prospectus et prospectus comitans non omnia continent informationes adnotationes cum SEC inposita. Ad pleniorem huius oblationis intelligentiam referas ad completam constitutionem, etiam exhibitionem, de Forma S-3 quae obtineri potest, ut supra dictum est. Dictiones in hoc supplemento prospectus orincorporatae referuntur et comitante prospectus circa contenta cuiuslibet contractus vel documenta alia non necessario completa sunt. Si contractum aliquod vel aliud documentum interponimus ut documentum exhibeat in adnotatione adfirmationis vel quodlibet aliud documentum quod in relatione in adnotatione adfirmatur cuius haec supplementi pars facit, legere debeas exhibere ad pleniorem intelligentiam documenti vel materiae implicatae. . Quaelibet propositio de contractu vel alio documento in totum ap- paret, referens ad ipsum documentum.

Wealso maintain a web site at www.guardionhealth.com, through which you can access our SEC filings. The information set forth onour web site is not part of this prospectus supplement or the accompanying prospectus.

INCORPORATIONOF DOCUMENTORUM REFERENTIA

Contexuimus adnotationem constitutionis de Forma S-3 cum SEC sub Securitatibus Act. Prospectus haec est pars propositionis adnotationee, sed enuntiatio adnotationes includit et incorporat referens informationis et ostendit. SEC permittit nos informationes "incorporateby referentes", quae in documentis continentur, cum SEC fundi, id quod significat magnas informationes detegere posse vobis referendo ad illa documenta potius quam ad illas in hoc prospecto includendo. Informationes quae a referenceis inserta pars huius prospecti existimatur et ea eadem cura legeris qua prospectus legeris. Informationes quae postea filemus cum SEC automatice renovabimus ac supersedeo informationes quae vel continentur vel relatione incorporata sunt in hoc prospecto et pars huius prospecti considerabitur a tempore documenta illa interposita sunt. SEC cum sec interposita sumus et in prospectu hoc incorporamus:

Wealso incorporamus referentes omnia documenta additamenta quae cum SEC sub terminis sectionum 13(a), 13(c), 14 vel 15 (d) Actus permutationis factae sunt post tempus prospecti huius supplementi, sed prior. ad finem oblationis pignoribus prospectus supplementum. Nos autem non sumus incorporandi, utrobique, documenta vel informationes quae ad normam SEC normae ponendae censentur et non limamus.

Youmay rogamus et dabimus tibi exemplum harum limationum nullo pretio, nos vocando (800) 873-5141 vel scribendo ad nos in hac inscriptione:

GuardionHealth Sciences, Inc.

2925Richmond Avenue, Suite 1200

Houston, TX 77098

Attn:Chief Executive Officer

GuardionHealth Sciences, Inc.

CommonStock

PreferredStock

DebtSecurities

Warrants

Iura

Units

Wemay offerunt et vendunt de tempore in tempus in una vel pluribus oblationibus, quaslibet communes stirpes, praelatas stipes, pignori debitores, warantizat mercari communes, praelatas stipes vel debiti pignoris, vel quamlibet compositionem premissorum vel singulariter pro unitatibus. uno vel pluribus ex aliis securitates constat, aggregatum oblationis initialis pretium non excedentem $ 75,000,000.

Thisprospectus praebet generalem cautiones. Quoties peculiarem genus vel seriem securitatis vendimus, certas condiciones securitates in supplemento prospecto huic oblatas exhibebimus. Prospectus supplementum et quaelibet paginae liberae scriptionis prospectus addere potest, renovatio vel mutatio notitiae in hoc prospecto contentae. Auctorizare etiam possumus vel liberius scripto prospectus, qui vobis in his oblationibus praebeantur. Prospectus, prospectus applicabilis, et quaevis prospectus liberae scripturae cognatae, ac documenta quaecunque in eo vel inde referentia inserta sunt, antequam in quibusvis securitatibus nostris investire debes.

Thespecific terms of any securities to be offered, and the specific manner in which they may be offered, will be described in oneor more supplements to this prospectus. This prospectus may not be used to consummate sales of any of these securities unlessit is accompanied by a prospectus supplement. Before investing, you should carefully read this prospectus and any related prospectussupplement.

Communis stirps nostra statim in The Nasdaq Capital Market sub signo "GHSI" ponitur. Die 17 Septembris 2020, ultima rettulit pretium nostrae stirpis communis $0,2275 pro portione. Prospectus applicabilis supplementum notitias continebit, ubi applicabilis, ut in quibusvis aliis enumeratis in Foro Nasdaq Capitali vel mercatu pignoribus vel aliis cautionibus permutandis, si quid obvolvitur prospectus supplementum. Prospecti emptores cautionum nostrarum incitantur ad obtinendas notitias de emporia securitatium nostrarum, ubi licet.

Haesecuritates directe vendi possunt a nobis, per negotiatores vel procuratores de tempore in tempus designatos, vel per underscriptores, negotiatores, vel per compositiones istarum modorum continua vel morata ratione. Vide consilium distributionis in hocprospecto. Prospectus supplementi pro quavis oblatione pignoribus nostris etiam assignare possumus rationem distributionis. Si qui procuratores, subscriptores vel negotiatores in venditione quarumlibet cautionum, in quibus hic prospectus liberatur, nomina eorum patefaciemus et ratione dispositionum cum eis in prospecto supplemento. Pretium tothe publici talis pignoris et retis proveniens expectamus ab omni tali venditione recipere etiam in prospectussupplement contineri.

Theaggregate market value of our outstanding common stock held by non-affiliates was approximately $37,743,778 million which wascalculated based on 85,470,512 shares of outstanding common stock held by non-affiliates as of September 18, 2020, and a priceper share of $0.4416, the closing price of our common stock on August 10, 2020. Pursuant to General Instruction I.B.6 of FormS-3, in no event will we sell securities pursuant to this registration statement with a value more than one-third of the aggregatemarket value of our common stock held by non-affiliates in any 12-month period, so long as the aggregate market value of our commonstock held by non-affiliates is less than $75.0 million. In the event that subsequent to the effective date of this registrationstatement, the aggregate market value of our outstanding common stock held by non-affiliates equals or exceeds $75.0 million,then the one-third limitation on sales shall not apply to additional sales made pursuant to this registration statement. We havenot sold any securities pursuant to General Instruction I.B.6 of Form S-3 during the 12 calendar months prior to, and including,the date of this registration statement.

Investingin securitates nostras varias pericula involvit. Vide "Periculum factores" pro pluribus informationibus de theseriscis contenta. Alia pericula describentur in supplementis prospectus actis sub titulo "Periculum Factors". Sectionem illam supplementorum actis prospecti retractare ad discussionem rerum, quae investitores in pignoribus nostris considerare debent.

Neque Securitates et Commissio Commercii Americae, nec ullius securitatis status Commissio has securitates approbavit vel improbavit, vel adaequationem vel accurationem huius prospecti vel cuiuslibet societatis prospecti supplementi. Quaevis repraesentatio contrarii criminale est.

Thedate of this prospectus is September 24, 2020.

TABLEOF CONTENTS

ABOUTTHIS PROSPECTUS

Hocprospectus est pars enuntiationis adnotationee quam cum securitates et Commissioni Exchange US interpositas, vel SEC, processu adnotatione "pluteae" utens. Sub hac adnotatione constitutionis fasciae, interdum in una vel pluribus oblatione communis stirpis praelatae vendere, varias cautionum debiti series et/vel cautiones quaslibet ex huiusmodi cautionibus redimere vel singulos vel unitates ex complexione constat. unus vel plures ex aliis pignoribus in una vel pluribus oblationibus usque ad summam pupam quantitatem $75,000,000. Prospectus haec tibi praebet generalem securitatium descriptionem, quam offerre licet. Quotienscumque speciem vel seriem securitatis sub hoc prospecto vendimus, prospectum praebebimus supplementum, quod de condicionibus illius oblationis plus certae notitiae continebit.

Thisprospectus omnes informationes inclusarum in propositione adnotatione non continet. Ad pleniorem intelligentiam offerendi pignoris, referas ad adnotationem constitutionis, etiam eius exhibitionem. Adde, renovatio mutationis in prospecto supplemento vel libero scripto prospectus alicuius informationis in hoc prospecto contentarum vel in documentis quae in hunc prospectum referuntur incorporati sumus. Auctoritatem etiam unum vel liberius scripto prospectus praeberi vobis possumus quae materiales notitias ad has oblationes pertinentes contineant. Prospectus hic, una cum prospectussupplement applicabili, quaevis evulgata liberae scripturae prospectus ac documenta, quae in prospectum hunc prospectum et supplementum applicabiles incorporantur, omnia materialia informationes ad munus applicabile complectetur. Diligenter legas tum prospectum tum prospectum applicabilem et supplementum cuiuslibet scripti liberorum prospectus cognatorum, una cum informationibus sub "Ubi More Information descriptis", antequam aliquid de cautionibus oblatis emendis.

Wehave not authorized any dealer, agent or other person to give any information or to make any representation other than those containedor incorporated by reference in this prospectus, any accompanying prospectus supplement or any related free writing prospectusthat we may authorize to be provided to you. You must not rely upon any information or representation not contained or incorporatedby reference in this prospectus or an accompanying prospectus supplement, or any related free writing prospectus that we may authorizeto be provided to you. This prospectus, the accompanying prospectus supplement and any related free writing prospectus, if any,do not constitute an offer to sell or the solicitation of an offer to buy any securities other than the registered securitiesto which they relate, nor do this prospectus, the accompanying prospectus supplement or any related free writing prospectus, ifany, constitute an offer to sell or the solicitation of an offer to buy securities in any jurisdiction to any person to whom itis unlawful to make such offer or solicitation in such jurisdiction. You should not assume that the information contained in thisprospectus, any applicable prospectus supplement or any related free writing prospectus is accurate on any date subsequent tothe date set forth on the front of the document or that any information we have incorporated by reference is correct on any datesubsequent to the date of the document incorporated by reference (as our business, financial condition, results of operationsand prospects may have changed since that date), even though this prospectus, any applicable prospectus supplement or any relatedfree writing prospectus is delivered or securities are sold on a later date.

Item notandum quod repraesentationes, warantizationes et conventiones a nobis factae in omni conventione, quae interponitur ut exhibitio alicui documento, quod in hoc prospectu incorporatum est, unice ad utilitatem partium ad talem conventionem, in aliquibus casibus, factae sunt. neque ullum consilium inter eos sponsionis causa inter partes collocandum esse censendum est. Praeterea huiusmodi repraesentationes, warantiae seu conventiones accurate erant sicut tempus factum et obnoxium talibus conditionibus, limitationibus et restrictionibus, quae in talibus pactis continentur. Quapropter huiusmodi repraesentationes, warantiae ac conventiones non sunt adhibendae ut accurate exprimatur status rerum nostrarum.

Prospectus ad consummandas cautionum nostrarum venditiones adhiberi non potest, nisi prospectus cum supplemento sit. Quocirca repugnantiae sunt inter aliquod prospectum supplementum, hoc prospectum ac documenta quaecunque in relatione inserta sunt, documentum recentissimis temporibus regere debet.

Aspermitted by the rules and regulations of the SEC, the registration statement, of which this prospectus forms a part, includesadditional information not contained in this prospectus. You may read the registration statement and the other reports we filewith the SEC at the SEC’s web site or at the SEC’s offices described below under the heading “Where You CanFind Additional Information.”

CompanyReferences

In hoc prospectus "Societas," "nos," "nos" et "nostra" ad Custos Scientiarum, Inc., corporationem Delaware, eiusque subsidiaria, nisi contextus aliud requirit.

RISKFACTORS

Tristitia in pignoribus nostris summum periculum involvit. Prospectus haec continet, et prospectus supplementum ad singulas cautiones nostras oblationes continebit, disceptatio periculorum, quae in cautionibus nostris collocatur. Priorto deliberativam de collocandis in nostris securitatibus, diligenter consideres factores specificos sub titulo "Periculi factores" in hoc prospecto et applicabili supplemento prospectus, una cum omnibus aliis informationibus contentis vel insertis referendo in prospecto supplemento vel apparitio. vel incorporatus per hoc prospectus referencein. Etiam pericula, incerta et suppositiones sub Item 1A, "RiskFactors" tractatas considerare debes, in Relatione Annua de Forma X-K pro fiscali anno finito die 31 Decembris 2019, interposita cum SEC in March30, 2020, et quaevis renovata. in nostra Quarterly Renuntiationes de Forma X-Q descriptae, quae omnia referendo incorporantur, et subinde ab aliis relationibus emendari, suppleri vel superari possunt, cum SEC in futuro et quamlibet prospectus ad particularem pertinentium limamus. oblatio. Pericula et incerta, quae descripsimus, non solas opponimus. Additamenta et incerta, quae nunc nobis nota sunt vel quae nunc immateriales putamus, operationes nostras etiam afficere possunt. Eventus cuiuslibet horum periculorum notorum vel ignotorum posset te perdere omnem vel partem obsidetionis in pignoribus oblatis.

PRAE-LOOKSTATEMENTS

Thisprospectus and any accompanying prospectus supplement, including the documents that we incorporate by reference, contains forward-lookingstatements within the meaning of Section 27A of the Securities Act of 1933, as amended (the “Securities Act”) andSection 21E of the Securities Exchange Act of 1934, as amended (the “Exchange Act”). Any statements in this prospectusand any accompanying prospectus supplement about our expectations, beliefs, plans, objectives, assumptions or future events orperformance are not historical facts and are forward-looking statements. These statements are often, but not always, made throughthe use of words or phrases such as “believe,” “will,” “expect,” “anticipate,”“estimate,” “intend,” “plan,” and “would.” For example, statements concerningfinancial condition, possible or assumed future results of operations, growth opportunities, industry ranking, plans and objectivesof management, markets for our common stock and future management and organizational structure are all forward-looking statements.Forward-looking statements are not guarantees of performance. They involve known and unknown risks, uncertainties and assumptionsthat may cause actual results, levels of activity, performance or achievements to differ materially from any results, levels ofactivity, performance or achievements expressed or implied by any forward-looking statement.

Quaecumque propositiones prospectus in universum sunt habiles sunt, respectu periculorum factores, de quibus in hoc prospectus et quodlibet comitatus prospectus supplementi. Prospectum hunc et quemlibet comitatum prospectum supplementum ac documenta, quae hic et in eo referimus, legas ac proposita exhibemus ad adnotationem constitutionis, cuius prospectusis haec pars est, omnino et intellectu ut eventus futuri nostri materialiter differant ab eo quod exspectamus. Pones informationes apparentes in hoc prospecto et aliquo comite prospectus supplementum, accuratam esse diem in operculo anteriori huius prospecti vel eiusmodi supplementi tantum prospecti. Quia periculum factores huius prospecti de quibus in pagina 5 et in eo incorporantur referentes, eventus actuales vel eventus causare possent materialiter differre ab iis quae in quibusvis propositionibus a nobis vel pro nobis factis prospicientibus factae sunt, non debetis ulterius fidere. vultus diceres. Praeterea, quaelibet propositio prospicienti solum loquitur de tempore quo factum est, et nos suscepimus obligationem quaelibet propositio prompta renovandi ad res vel circumstantias reflectendi, post tempus quo constitutionis factae vel cogitationis eventum inexcussum est. praesagia. Novae res subinde emergunt, neque forus est possibile praedicere quae res oriantur. Praeterea non possumus perpendere ictum uniuscuiusque factoris in negotio nostro, vel quantum ad quemlibet factorem, vel concursum factorum, ut effectus actuales differant materialiter ab iis quae in quibusvis propositionibus deinceps continentur. Informationes quae in hoc prospecto et quovis comitatu prospecto supplemento, ac praesertim propositiones promptas, his cautionibus.

USEOF PROCESSIBUS

Exceptas described in any prospectus supplement and any free writing prospectus in connection with a specific offering, we currentlyintend to use the net proceeds from the sale of the securities offered under this prospectus for general corporate purposes, includingthe development and commercialization of our products, research and development, general and administrative expenses, business,license or technology acquisitions, and working capital and capital expenditures. We may also use the net proceeds to repay anydebts and/or invest in or acquire complementary businesses, products, or technologies, although we have no current commitmentsor agreements with respect to any such investments or acquisitions as of the date of this prospectus. We have not determined theamount of net proceeds to be used specifically for the foregoing purposes. As a result, our management will have broad discretionin the allocation of the net proceeds and investors will be relying on the judgment of our management regarding the applicationof the proceeds of any sale of the securities. Pending use of the net proceeds, we intend to invest the proceeds in short-term,investment-grade, interest-bearing instruments.

Singulae cautiones sub hoc prospecto offerimus, intentum usum retis ex illa oblatione in prospectus theologico supplemento procedente describemus. Actualis copia rete quod in particulari usui impendimus a pluribus causis dependet, inclusa, expensorum capitalium futurorum, summa pecuniae, quae ab operationibus nostris exiguntur, et incrementa futuri reditus, siqua igitur lata discretione retinebimus. in usu retia procedit.

DESCRIPTIONOF INSTRUMENTUM CAPITIS

General

Hanc descriptionem capitis nostri, cum quibusvis additis informationibus includimus in quovis supplemento applicabilium actis liberorum scriptorum prospectus, summatim materialia vocabula et praescripta communis stirpis et generis praelati, ut sub hoc prospecto offeramus. Cum verba quae infra digesta sunt, generaliter ad quemvis stirpium communium futuram praelatarum stirpem pertinebit, ut offeramus, particularia cuiuscumque generis vel seriei harum cautionum in pleniore loco in supplemento prospecti applicabili describemus. Ad integras condiciones communis stirpis nostrae et stirpis praelatae, placet referre notam certificatorium Incorporationis, ut emendatum ( " certificatorium Incorporationis " ) et secundae nostrae emendatae et confirmatae per leges ( " Bylaws " ) quae incorporantur per comparationem in enuntiatione adnotatione cuius haec prospectusis pars vel in prospectu huius prospecti vel cuiuslibet prospecti supplementi applicabili incorporari potest. Termini harum cautionum etiam affici possunt Lege Corporation Generalis Delaware ( "DGCL"). Summarium infra et quod in omni prospectu supplementi seu libero scripto prospectus affine, idonee sunt in integritate per respectum ad nostram Incorporationem certificationem et per leges nostras emendatas et confirmatas.

Asof the date of this prospectus, capitalis stirpis auctus ex 250,000,000 portionum communis stirpis, $0.001 par valueper participes, et 10,000000 portiones praelati generis, $0.001 par valor per participes. Tabula nostra iura et optiones praelatas stirpis subinde stabilire potest. Sicut die 18 mensis Septembris anno 2020, partes erant 88,327,312 nostrae communis stirpis latis et notae, et nullae praelati generis partes editae et praestantes.

CommonStock

Auctoritas est permittere ad summam 250,000,000 portionum communis stirpis, par valoris $0.001 per participes. Detentores communitatis unius suffragii pro unaquaque portione tenentur de omnibus rebus suffragio nostro sublatis. Habitatores communitatis iura suffragii cumulativo non habent. Omnes portiones communis stirpis quae ab hoc proferuntur, plenarie solvantur et non inaccessibiles, excepta portiones communis stirpis quae in exercitio communis stirpis ferat vel subscriptio iura, si qua sunt.

Praeterea, possessores communis stirpis non habent iura praeemtiva vel conversionem vel alia subscriptio iura. In nostra liquidatione, dissolutio- nis flexibus, possessores communis stirpis ius sunt participes omnium bonorum, qui remanent post solutionem omnium onerum, ac optiones liquidationum quarumlibet excellentium partium praelatarum stirpis. Subiectis optionibus quae ad quascunque partes praelatae stirpis praestantes applicari possunt, possessores communis stirpis ad dividendos recipiendos competit, si quae, ut ex tempore in tempus declaratum est, Tabulae Directoris ex bonis nostris quae licite suppetunt. Tales dividendi, si qui sunt, in pecunia numerata, in bonis vel in partibus capitalis stipendii.

Theholders of a majority of the shares of our capital stock, represented in person or by proxy, are necessary to constitute a quorumfor the transaction of business at any meeting. If a quorum is present, an action by stockholders entitled to vote on a matteris approved if the number of votes cast in favor of the action exceeds the number of votes cast in opposition to the action, withthe exception of the election of directors, which requires a plurality of the votes cast.

PreferredStock

Moderatores nostri auctoritatem, sine ulteriori actione a cauponibus, usque ad 10,000,000 portionum praeferentium in una vel plurium serie edant, ac figere designationes, potestates, optiones, privilegia, ac relativum participationem, optionalem, vel specialem iuribus. ut qualitates, limitationes seu restrictiones praelatae stirpis, inclusa iura dividenda, iura conversionis, iura suffragii, redemptionis termini, et optionum liquidationum, quae quaevis vel omnia maiora sint quam iura communis stirpis. Tabula nostra directorium, sine auctorum approbatione, potest convertibilem stirpem praelatam cum suffragio, conversione, aliisve iuribus quae adversatur potentiae suffragii et aliis iuribus possessorum communis stirpis adversae. Preferredstock cito edici potest cum terminis morandi computatis vel mutationem regiminis impedire vel remotionem administrationis difficiliorem reddere. Accedit, exitus praelati generis effectum habere potest minuendi annonae nostrae communis stirpis, et adversatur suffragiis et aliis iuribus possessorum communis stirpis. In praesenti, nulla consilia habemus in praelatis stirpis huius oblationis anyshares edendi.

Anti-TakeoverEffects of Provisions of Delaware State Law

Praescripta sectio 203 Corporation Delaware Legis Generalis gubernata sunt. In genere, Sectio 203 vetat corporationem publicDelaware, quominus "negotium coniunctio" cum "soptentore" intersit, pro aperiendo triennio post tempus transactionis in quo persona factus est auctor interest, nisi:

Ingeneral, Section 203 defines a “business combination” to include mergers, asset sales and other transactions resultingin financial benefit to a stockholder and an “interested stockholder” as a person who, together with affiliates andassociates, owns, or within three years did own, 15% or more of the corporation’s outstanding voting stock. These provisionsmay have the effect of delaying, deferring or preventing changes in control of our company.

Ourcertificatio incorporationis et legum nostrarum complura includunt commeatus qui inimicitias vel moras vel praeventiones in potestate nostrarum moderatorum vel turmarum administrationis deterrere potuerunt, cum sequentibus:

Boardof Directores Vacancies. Leges nostrae auctores tantum moderatorum tabularum nostrarum permittunt ut directoria vacantia, inclusa recenter creata sedilia, impleant. Praeterea numerus moderatorum, qui tabulam nostram constituunt moderatorum, permittetur solum per maiorem suffragium totius nostrae moderatorum tabulae resolutae adoptari. Praescripta haec impediret ne stipes a magistrorum tabularum nostrarum solutione augeretur ac deinde moderatorum tabularum potestatem potiretur, cum suis nominatis vacationes inde implevit. Hoc difficilius erit compositionem nostrae tabulae moderatorum mutare et continuitatem administrationis promovere.

Abilityof Stockholders to Call Special Meetings. Our Certificate of Incorporation and Bylaws provide that stockholders can only calla special meeting if stockholders holding over 50% of all issued and outstanding shares of the Corporation entitled to vote ata meeting do so.

AdvanceNotice Requisita. Nostrae Bylaws praemonere rationes ad propositas stockholder quae ad nominationem candidatorum electionis tamquam moderatores vel nova negotia ad conventus stockholders adducendas esse statuunt. Haec agendi ratio provideat ut noticia talium propositionum auctorum opportune in scriptis exhibeatur Secretario Societatis ante conventui de quo agetur. Notitia certa continere debet in Bylaws.

ExclusiveForum provisio. Iuxta forum exclusivum praescriptum in Bylaws, nisi Societas ad electionem fori alterius scripto consentit, Curia Cancellariae Civitatis Delaware erit unicum et exclusivum forum ad certas actiones civitatis fundatas actiones quaedam derivativas. actiones seu acta pro Societate; actio fideiussoriae fideiussoris a praefecto, a rectore, operario vel sociis Societatis; aliquem vindicare sub lege corporatum Delaware; et quamlibet actionem asserentem a rebus internis administrari doctrinam.

NoCumulative Voting. The Delaware General Corporation Law provides that stockholders are not entitled to cumulate votes in theelection of directors unless a corporation’s certificate of incorporation provides otherwise. Our certificate of incorporationdoes not provide for cumulative voting.

Maluit Issuanceof Undesignated Stock. Tabula moderatorum nostra sine ulteriori actione a nostris auctoribus auctoritatem habebit, ut usque ad 10,000 millia unciarum indesignatorum praelatarum stirpis cum iuribus et optionibus, inter iura suffragii, subinde a nostris moderatoribus designetur. Exsistentia authentica, sed non emissae portiones potioris stirpis, nostrae tabulae moderatorum difficilius reddere aut dissuadere conatum ad imperium nostrum obtinendum per merger, teneram condicionem, procuratorem certaminis vel alia media.

varius

Ourcommon stock is listed on The Nasdaq Capital Market under the trading symbol “GHSI.”

TransferAgent et Registrarium

TheTransfer Agent and Registrarium for our stock is VStock Transfer, LLC.

DESCRIPTIONOF DEBT SECURITIES

Sequens descriptio, una cum informationibus in quibusvis supplementis seu scriptionibus liberis prospectus applicabilium includimus, materias leges et praescripta debitorum pignorum compendio quam sub hoc prospecto offeramus. Wemay proventus debiti pignoris in una vel pluribus serie, prout vel senior vel subordinatus debiti vel senior vel subordinatus convertibledebt. Cum verba quae infra digesta erunt generaliter ad quascumque cautiones futuri debiti praedes offerimus sub hoc prospecto, particularia cuiusvis pignoris debiti termini describemus, ut fusius in prospectus supplementoris gratis scriptionis prospectus applicabilem praebeamus. Termini pignoris debiti, quod sub prospecto supplemento offerimus, differre possunt a terminis infrascriptis. Nihilominus nulla prospectus supplementum fundamentaliter immutabit verba quae in hoc prospectusore proponuntur securitatem praebeant quae non est relatus et descriptus in hoc prospecto tempore suae efficaciae. Prospectus huius temporis, praedes non habemus praestantes debitores. Nisi aliud contextus postulat, quoties "indenturas" referimus, etiam de aliquibus indenturis supplementalibus referimus quae termini certae seriei pignoris debiti denotant.

Aliquas cautiones seniores debiti sub seniori indentura, quod cum commissario in seniorindentura nominato intrabimus. Quascumque cautiones subordinatas sub indentura subordinata et quaslibet supplementales indenturas quas cum commissario nominato in subordinata indentura intrabimus. Formas harum documentorum interpositas exhibemus cum propositione adnotatione adnotatione, cuius prospectus haec pars est, et supplementa indenturae et formae debiti pignoris, cum termini pignoris debiti exhibeantur, interponitur sicut exhibitio ad adnotationem propositionis cuius haec prospectusis. pars vel incorporetur relationibus relationum quas cum SEC.

Theindentures will be qualified under the Trust Indenture Act of 1939, as amended (the “Trust Indenture Act”). We usethe term “trustee” to refer to either the trustee under the senior indenture or the trustee under the subordinatedindenture, as applicable.

Summaria sequentia materialia praescripta senioris debiti pignoris, debiti pignoris subordinati ac indenturae subditae, ac in universum secundum idoneos, omnia praescripta indenturae et quaevis supplementa indenturae applicabiles ad certam seriem pignoris debiti. Hortamur vos ut perlegent prospectus supplementorum applicabilium et quaevis scripturae liberae prospectus ad pignores debiti pertinentes, quae sub hoc prospecto offeremus, necnon plenae indenturae quae condiciones pignoris debiti continet. Praeterquam quod aliud indicati sumus, termini indenturae antiquioris et indenturae subordinatae idem sunt.

Generalis

Theterms of each series of debt securities will be established by or pursuant to a resolution of our Board of Directors and set forthor determined in the manner provided in an officers’ certificate or by a supplemental indenture. Debt securities may beissued in separate series without limitation as to aggregate principal amount. We may specify a maximum aggregate principal amountfor the debt securities of any series. We will describe in the applicable prospectus supplement the terms of the series of debtsecurities being offered, including:

Conversionor Exchange Rights

In prospecto applicabili supplemento exponemus verba sub quibus pignoris debiti series intoor commutabilis pro communi nostra stirpe, praelata stirpe vel aliis cautionibus (inclusa securitates tertiae partis) converti potest. Praescripta includimus utrum conversio vel commutatio sit facienda, in optione possessoris vel optionis nostrae. Praevisiones includere possumus secundum quas numerus portionum communis stirpis nostrae, praelatae stirpis vel aliae cautiones (inclusa securitates tertiae partis) ut possessores seriei pignoris debiti recipiant, aequilibrationes subiaceant.

Consolidatio, Merger vel Sale

Unlesswe provide otherwise in the prospectus supplement applicable to a particular series of debt securities, the indentures will notcontain any covenant that restricts our ability to merge or consolidate, or sell, convey, transfer or otherwise dispose of allor substantially all of our assets. However, any successor to or acquirer of such assets must assume all of our obligations underthe indentures or the debt securities, as appropriate. If the debt securities are convertible into or exchangeable for our othersecurities or securities of other entities, the person with whom we consolidate or merge or to whom we sell all of our propertymust make provisions for the conversion of the debt securities into securities that the holders of the debt securities would havereceived if they had converted the debt securities before the consolidation, merger or sale.

Eventsof Default in Indenture

Nisi aliud providebimus in supplemento prospecti ad certam seriem debiti pignoris applicanda, sequentia sunt defalta sub indenturis respectu quarumcumque pignitatum debiti, quae edimus:

Prospectus applicabilis in singulis describemus supplementum adiectis eventibus defaltis quae ad debitasecuritatum seriem pertinentes pertinentes.

Ifan eventus defaltae respectu pignitatum debiti cuiuslibet seriei occurrit et continuatur, praeter eventum defaltae specificatae in ultimo puncto suprascripto, commissarium vel detentores saltem 25% in aggregato principali quantitatem praestantium debitorum illius. série noticiam habituri nostro scripto et commissario, si per tales detentores denuntietur, noticiamus inde solutum principale, premium, siquis, et usuras, si qua sunt, immediate debite et solvendas. Si vero defectus eventus oriatur per eventum certae decoctionis, insolventiae vel reordinationis eventuum, persolutum principale, premium, si quis, et usurae, si quae extiterint, de quavis pignore debiti tunc praestans, debita et solvenda sine omni v. noticiam seu actionem ex parte fideicommissarii vel cuiuslibet possessoris.

Theholders of a majority in principal amount of the outstanding debt securities of an affected series may waive any default or eventof default with respect to the series and its consequences, except defaults or events of default regarding payment of principal,premium, if any, or interest, unless we have cured the default or event of default in accordance with the indenture. Any waivershall cure the default or event of default.

Subiectis terminis indenturis, si eventus defaltae sub indentura occurrat et perseveret, fideicommissarius obligatus erit, quaelibet iura vel potestates sub tali indentura exercere, ad instantiam vel directionem cuiuslibet tenentium eiusdem applicabilis. pignoris debiti seriem, nisi tales detentores rationabilem indempnitatem vel securitatem prebuerint commissarium satisfactorium contra aliquod dampnum, debitum vel expensam. Detentores maioris in principali quantitate praeclari debiti pignoris cuiuscumque seriei, ius erit dirigere tempus, modum et locum agendi cuiuslibet procedendi pro quovis remedio contra commissarium, vel aliquam fidem vel potestatem in fideicommissarium collatam exercendi, cum v. respectu pignoris debiti illius seriei, dummodo ;

Theindentures will provide that if an event of default has occurred and is continuing, the trustee will be required in the exerciseof its powers to use the degree of care that a prudent person would use in the conduct of its own affairs. The trustee, however,may refuse to follow any direction that conflicts with law or the indenture, or that the trustee determines is unduly prejudicialto the rights of any other holder of the relevant series of debt securities, or that would involve the trustee in personal liability.Prior to taking any action under the indentures, the trustee will be entitled to indemnification against all costs, expenses andliabilities that would be incurred by taking or not taking such action.

Securitatum debiti cuiuslibet seriei possessor ius erit instituendi sub indenturis procedendi vel instituendi areceiveri vel commissarii, vel alia remedia quaerendi tantum, si:

Theselimitations do not apply to a suit instituted by a holder of debt securities if we default in the payment of the principal, premium,if any, or interest on, the debt securities, or other defaults that may be specified in the applicable prospectus supplement.

Periodice propositiones cum fideicommissario de nostro obsequio cum certis testamentis in indenturis plicabimus.

Indenturae providebunt ut, si defalta inciderit et continuata sit et actu responsalis fideicommissarius notus sit, debet fideicommissarium mittere unicuique noticiam defaltam infra ante 90 dies postquam incidit et 30 dies postquam ab eo cognitum est. per responsalem fideicommissarium vel scripto notum de eo recipitur a fideicommissario, nisi talis defalta fuerit vel remittatur. Excepto casu de defalta in solutione principali vel premii vel interesse alicuius debiti pignoris aliquibus aliis defaltis in indentura determinatis, custodietur commissarius in retencione talis notie si et tam longas tabulam directoris. Consilium exsecutivum vel fiduciaria moderatorum, vel responsales fideicommissarii, bona fide decernunt detentionem notitiam esse in commodis detentoribus pertinentis seriei pignoris debiti.

Modificationof Indenture; Waiver

Subiectis terminis indenturae pro quavis serie debiti pignoris, quod nos et fideicommissarius mutet indentura sine consensu cuiuslibet tenentium respectu sequentium specialium rerum;

Inaddition, under the indentures, the rights of holders of a series of debt securities may be changed by us and the trustee withthe written consent of the holders of at least a majority in aggregate principal amount of the outstanding debt securities ofeach series that is affected. However, subject to the terms of the indenture for any series of debt securities that we may issueor otherwise provided in the prospectus supplement applicable to a particular series of debt securities, we and the trustee mayonly make the following changes with the consent of each holder of any outstanding debt securities affected:

Dimittite

Eachindenture provides that, subject to the terms of the indenture and any limitation otherwise provided in the prospectus supplementapplicable to a particular series of debt securities, we may elect to be discharged from our obligations with respect to one ormore series of debt securities, except for specified obligations, including obligations to:

Inorder to exercise our rights to be discharged, we will deposit with the trustee money or government obligations sufficient topay all the principal of, and any premium and interest on, the debt securities of the series on the dates payments are due.

Forma, commutatio et translatio

Securitates debiti uniuscuiusque seriei solum in forma plene descriptis sine coupons dabimus et, nisi aliud in accessione prospecti supplementi, in denominationibus 1,000 $, et quamlibet integralem multiplicem, nominabimus. Indenturae providebunt ut securitates debiti seriei in forma globali temporaria vel permanenti praebuerint et tamquam pignores libri-introversi, qui apud nos deponantur, vel ex parte depositarii spera Company vel alia depositaria a nobis nominata et in prospectussupplement notentur. respectu illius seriei. Vide infra pro ulteriori descriptione terminorum ad quemlibet librum-ingressum pignoribus pertinentibus.

Atthe option of the holder, subject to the terms of the indentures and the limitations applicable to global securities describedin the applicable prospectus supplement, the holder of the debt securities of any series can exchange the debt securities forother debt securities of the same series, in any authorized denomination and of like tenor and aggregate principal amount.

Subiectis indenturarum terminis ac limitationibus ad securitates globales pertinentes in supplemento prospectus applicabili expositae, possessores debiti pignoris debiti cautiones commutationis vel adnotatione translationis rite munitae exhibere possunt vel cum forma translationis in eo rite peractae confirmatum. si ita exigatur a nobis vel registrum securitatis, in officio haecuritatis registrarii vel officii alicuius procuratoris trans- lati a nobis ad hoc designati. Nisi aliter cautum sit in pignoribus, quas possessor praesentes transferendi vel commutandi dederit, nullum servitii crimen pro quavis translationis translatione permutatione praestabimus, sed solutionem cuiusvis vectigalium vel aliarum rerum publicarum postulare debebimus.

Nos nominabimus in prospectus applicabili supplemento ad registrarium securitatis, et quodlibet procuratorem transferendi praeter registrarium securitatis, quod initio pro pignore quovis debiti designamus. Licet aliquando designare additiones procuratores translationis vel designationem alicuius translationis agentis rescindere vel approbare mutationem in officio, per quod aliquis actus transmutationis agentis, excepto quod debebit ponere procuratorem translationem in singulis locis solutionis pro debitis pignoribus. singulas series.

Ifwe elect to redeem the debt securities of any series, we will not be required to:

InformationConcerning commissarium

Thetrustee, other than during the occurrence and continuance of an event of default under an indenture, undertakes to perform onlythose duties as are specifically set forth in the applicable indenture and is under no obligation to exercise any of the powersgiven it by the indentures at the request of any holder of debt securities unless it is offered reasonable security and indemnityagainst the costs, expenses and liabilities that it might incur. However, upon an event of default under an indenture, the trusteemust use the same degree of care as a prudent person would exercise or use in the conduct of his or her own affairs.

Paymentand dare agentium

Nisi si aliud in prospectus supplementi applicabili indicabimus, dabimus usuras usuras cuiusvis pignoris debiti ex quovis usurae solutione datae personae, cuius nomine pignores debiti vel praedecessoris unus vel plures praedes scripti sunt in clausula negotiorum in regulari. recordum date pro foenore mercedem.

Wewill pay principal of and any premium and interest on the debt securities of a particular series at the office of the paying agentsdesignated by us, except that unless we otherwise indicate in the applicable prospectus supplement, we will make interest paymentsby check that we will mail to the holder or by wire transfer to certain holders. Unless we otherwise indicate in the applicableprospectus supplement, we will designate the corporate trust office of the trustee as our sole paying agent for payments withrespect to debt securities of each series. We will name in the applicable prospectus supplement any other paying agents that weinitially designate for the debt securities of a particular series. We will maintain a paying agent in each place of payment forthe debt securities of a particular series.

Predictam pecuniam solvimus procuratori vel fideicommissario pro solutione principalis vel cuiuslibet premium vel interesse cuiuslibet debiti pignoris, quod in fine duorum annorum remanet inordinatus, post tale principale, premium vel usuram debitam et solvendam nobis reddetur. et extunc nobis spectet possessor debiti securitatis ad solvendum inde.

Regendi legem

Theindentures and the debt securities will be governed by and construed in accordance with the laws of the State of New York, exceptto the extent that the Trust Indenture Act is applicable.

RankingDebt Securities

Securitas debiti subordinata secura erit et subordinata erit et minor in prioritate solutionis ad quaedam alia indebiti obligatio quatenus in prospecto supplemento describitur. Indenturae subordinatae non limitant quantitatem debitorum subordinatorum ut exeant. Etiam non limitat nos ab aliquo alio facto vel securo debiti.

Thesenior debt securities will be unsecured and will rank equally in right of payment to all our other senior unsecured debt. Thesenior indenture does not limit the amount of senior debt securities that we may issue. It also does not limit us from issuingany other secured or unsecured debt.

DESCRIPTIONOF warantizat

Sequens descriptio, una cum informationibus in quibusvis supplementis et spe- culis gratis scribendis includere licet, materias terminos ac praescriptam postulationum compendio, quae sub hoc prospecto offerre possumus, quae ex mercimoniis communibus mercandis, praelatis stipendio vel aere alieno. securitates et in una vel pluribus ferantur serie. Warrants offerri possunt independenter vel una cum stipite communi, praelatas cautiones vel stipes vel debiti quacunque prospectussupplement oblatas, et ab illis pignoribus adiungi vel separari possunt. Cum verba infra digesta fere ad aliquas cautiones adhibebimus quae sub hoc prospecto offeremus, singula nomina cuiuslibet enunciationum series describemus, quae uberius offerre possumus in supplemento applicabili prospectus et quodvis liberum scriptionis prospectum applicabile. Conditiones quaelibet sub supplemento prospectus propositae possunt ab illis infra descriptis differre. Nihilominus, nulla prospectus supplementum, verba quae in hoc prospecto explicantur vel funda- mentaliter mutabunt vel securitatem praebent quae non est relatus et descriptus in hoc prospecto tempore suae efficaciae.

Wemay issue the warrants under a warrant agreement that we will enter into with a warrant agent to be selected by us. If selected,the warrant agent will act solely as an agent of ours in connection with the warrants and will not act as an agent for the holdersor beneficial owners of the warrants. If applicable, we will file as exhibits to the registration statement of which this prospectusis a part, or will incorporate by reference from a Current Report on Form 8-K that we file with the SEC, the form of warrant agreement,including a form of warrant certificate, that describes the terms of the particular series of warrants we are offering beforethe issuance of the related series of warrants. The following summaries of material provisions of the warrants and the warrantagreements are subject to, and qualified in their entirety by reference to, all the provisions of the warrant agreement and warrantcertificate applicable to a particular series of warrants. We urge you to read the applicable prospectus supplement and any applicablefree writing prospectus related to the particular series of warrants that we sell under this prospectus, as well as the completewarrant agreements and warrant certificates that contain the terms of the warrants.

Generalis

Prospectus applicabilis in supplemento verborum ad seriem postulationum pertinentium describemus, inter quas:

Exerciseof Warrants

Eachwarrant will entitle the holder to purchase the securities that we specify in the applicable prospectus supplement at the exerciseprice that we describe in the applicable prospectus supplement. Unless we otherwise specify in the applicable prospectus supplement,holders of the warrants may exercise the warrants at any time up to the specified time on the expiration date that we set forthin the applicable prospectus supplement. After the close of business on the expiration date, unexercised warrants will becomevoid.

Holdersof warantizatio potest exercere warantum tradendo libellum repraesentans warantum una cum certa informatione exercenda, et solvendo debitam quantitatem ad procuratorem warantum in pecunia statim praesto, prout in prospectus applicabilis supplementi. Dicemus in parte adversa certificamenti et in prospectussupplement applicabili informationes quas tenens warantum requiretur ad nos vel ad procuratorem warantum tradendum prout applicabile est.

Recepta solutionis debite et certificatorium cautionis rite peractae et rite peractae in officio fideicommissi agentis vel cuiuslibet alterius officii, quod in applicatione prospecti supplementi indicatum est, super tali exercitio praestabimus et liberabimus. Si pauciores omnes warantorum per testimonium per testimonium expressi exercentur, tunc novum libellum de reliqua parte warantorum dabimus. Si in prospectus applicabili supplemento ita indicamus, possessores cautionum ex toto vel ex parte usus pretium pro cautionibus dedere possunt.

Enforceabilityof Rights by Holders of Warrants

Si electus, quilibet procurator warantus tantum agat sicut procurator noster sub convenientia waranto applicabili et nullam procurationis vel fideicommissam cum aliquo possessore warantizabit aliquam obligationem vel fideicommissam assumere. Una societas ripae vel fiduciae agere potest ad warantum agente plus quam unus exitus de warantia. Procurator warantus nullum officium vel responsabilitatem habebit, si quis defaltam a nobis sub stipulatione vel waranto applicabili, non possidet ullum officium vel responsabilitatem ad procedendum in iure vel aliter, vel ad nos postulandum. Quilibet autem warantizatus, sine consensu actis waranti agentis vel alterius cuiuslibet waranti tenens, per competentem actionem legalem ius suum exercendi cogat, et securitates acquisitas ad exercitium, et warantizandum recipiat.

DESCRIPTIONOF IURIBUS

General

Wemay ius dat stipendiis nostris ad mercandas portiones communis stirpis nostrae, praelata stirpe vel aliis pignoribus in hoc prospecto descriptos. Iura separatim offerre possumus vel cum uno vel pluribus additis iuribus, pignoribus debiti, praelatis, communis stirpis vel cautionis, vel aliquarum cautionum coniunctio in forma unitatum, prout in prospectussupplendis applicabili descriptus est. Singulae iurium series edentur sub disiunctis iuribus conventionis inter nos ineundos et societatem argentariam ortrust, ut iura agentis. Iura agentis aget unice ut procurator noster in nexu cum testimonialibus quae ad iura seriei libellorum pertinentia nec aliquam obligationem vel relationem procurationis vel fideicommissi assument vel cum aliquibus possessoribus iurium testimonialibus vel commodis possessoribus iurium. Sequens descriptio quaedam generalia iurium condiciones et provisiones proponit, ad quae supplementum quodvis prospectus referat. Termini particulares iurium, ad quae prospectus supplementum referat et quatenus, si quae sunt, ad quae generalia praescripta iuribus oblatis applicata sint, in prospectus supplementi applicabili describuntur. Quatenus quaelibet particularia iurium, iurium consensus vel iurium testimoniales in prospectus supplemento ab aliquo terminorum infra descriptorum differunt, termini infra descriptos ab illo prospectus supplemento supersedi habebuntur. Hortamur vos ut iura convenientia et iura certificatoriae informationis applicabiles legatis antequam decernatis an aliquod nostrum ius redimere possit. Prospectus supplementum dabimus sequentes condiciones iurium edendae:

Eachright will entitle the holder of rights to purchase for cash the principal amount of shares of common stock, preferred stock orother securities at the exercise price provided in the applicable prospectus supplement. Rights may be exercised at any time upto the close of business on the expiration date for the rights provided in the applicable prospectus supplement.

Holdersmay iura exercent de quibus in supplemento prospectus applicabilium describitur. Super recepcione solutionis et iurium certificatorium rite absolutum et rite peractum ad corporatum fideicommissum officium iurium agentis vel cuiuscumque alterius officii in prospectussupplement indicato, nos, quam primum expedit, deinceps portiones communis stirpis, praelata stirpe vel aliis pignoribus. prout applicabile est ad iurium exercitium acquirendum. Si minus quam omnia iura quae in quibusvis iuribus oblatione exercentur, securitates unsubscriptas directe praebere possunt aliis personis quam cauponibus, vel per procuratores, underscriptores vel negotiatores vel per compositionem huiusmodi modorum, etiam juxta ordinationes standum, ut dictum est. in locum prospectus supplementum.

RightsAgent

Therights agent for any rights we offer will be set forth in the applicable prospectus supplement.

DESCRIPTIONOF UNITS

Sequens descriptio, una cum informationibus in quibusvis supplementis et spe- culis gratis scribendis applicabiles complecti possumus, materialia verba et praescripta unitatum, quae sub hoc prospecto offerimus, summat.

Whilethe terms we have summarized below will apply generally to any units that we may offer under this prospectus, we will describethe particular terms of any series of units in more detail in the applicable prospectus supplement. The terms of any units offeredunder a prospectus supplement may differ from the terms described below. However, no prospectus supplement will fundamentallychange the terms that are set forth in this prospectus or offer a security that is not registered and described in this prospectusat the time of its effectiveness.

Volumus lima ut exhibeat adnotationem propositionis cuius hic prospectus pars est vel incorporamus referentes ex relatione Current de forma 8-K quod limamus cum SEC, forma concordiae unitatis quae termini seriei unitatum describit. offerunt, et quaevis pacta supplea, antequam editae sint paginae paginarum paginarum. Sequuntur summaria terminorum materialium et praescriptorum iunctorum subiciuntur, et in toto secundum idoneos sunt, praescripta unitatis consensus et quaevis pacta suppletiva ad certam unitatum seriem pertinentia. Prospectus supplementorum applicabilium te hortamur legere ad seriem particularium unitatum quas sub hoc prospecto vendimus, necnon integram concordiam et quaelibet pacta suppletiva quae unitatum vocabula continent.

Generalis

Wemay issue units comprised of one or more debt securities, shares of common stock, shares of preferred stock and warrants in anycombination. Each unit will be issued so that the holder of the unit is also the holder of each security included in the unit.Thus, the holder of a unit will have the rights and obligations of a holder of each included security. The unit agreement underwhich a unit is issued may provide that the securities included in the unit may not be held or transferred separately, at anytime or at any time before a specified date.

Prospectus applicabilium verba seriei unitatum, quae possidet, supplere demonstrabimus:

Theprovisions described in this section, as well as those described under “Description of Capital Stock,” “Descriptionof Debt Securities” and “Description of Warrants” will apply to each unit and to any common stock,preferred stock, debt security or warrant included in each unit, respectively.

UnitAgent

Nomen et inscriptio agentis unitatis, si quaelibet, pro quibuslibet unitatibus quas offerimus, in supplemento prospectus applicabili patebit.

Issuancein Series

Wemay unitates in tantis ponderis et numerosis seriebus distinctas, prout decernimus, edunt.

Enforceability of Rights by Holders of Unitates

Eachunit agent will act solely as our agent under the applicable unit agreement and will not assume any obligation or relationshipof agency or trust with any holder of any unit. A single bank or trust company may act as unit agent for more than one seriesof units. A unit agent will have no duty or responsibility in case of any default by us under the applicable unit agreement orunit, including any duty or responsibility to initiate any proceedings at law or otherwise, or to make any demand upon us. Anyholder of a unit may, without the consent of the related unit agent or the holder of any other unit, enforce by appropriate legalaction its rights as holder under any security included in the unit.

Nos, procuratores unitatis et quilibet eorum procuratores scripti possessoris cuiuslibet unitatis libellum tractare sicut absolutum possessorem e quibus certificatorium illud cuiuslibet rei cognosci potest et sicut persona competit iura exercere ad unitates ita petitas, non obstante aliquo. noticiam contra. Vide "Legal Occupatio Securitatum."

LICENTIA SECURITIES

Wecan issue securities in registered form or in the form of one or more global securities. We describe global securities in greaterdetail below. We refer to those persons who have securities registered in their own names on the books that we or any applicabletrustee or depositary or warrant agent maintain for this purpose as the “holders” of those securities. These personsare the legal holders of the securities. We refer to those persons who, indirectly through others, own beneficial interests insecurities that are not registered in their own names, as “indirect holders” of those securities. As we discuss below,indirect holders are not legal holders, and investors in securities issued in book-entry form or in street name will be indirectholders.

Liber-EntryHolders

Wemay cautiones in libro-introitu tantum formant, sicut in supplemento prospecti applicabili exprimemus. Securitates hoc modo repraesentari possunt per unum vel plures securitates globales descripti nomine institutionis nummariae quae eas habet ut depositaryon pro aliis institutis nummariis quae participes sunt in systemate depositario. Hae institutiones participantes, quae ad participes referuntur, vicissim utilitates habent in securitate pro se vel suis clientibus.

Onlythe person in whose name a security is registered is recognized as the holder of that security. Global securities will be registeredin the name of the depositary or its participants. Consequently, for global securities, we will recognize only the depositaryas the holder of the securities, and we will make all payments on the securities to the depositary. The depositary passes alongthe payments it receives to its participants, which in turn pass the payments along to their customers who are the beneficialowners. The depositary and its participants do so under agreements they have made with one another or with their customers; theyare not obligated to do so under the terms of the securities.

Ita fit, investitores securitatis globalis in securitates securitatis non directe possidebunt. Pro utilitates in globalsecuritate possidebunt, per argentariam, sectorem vel alia Instituta nummaria, quae participant de ingressu systematis depositarii usuram per participem tenet. Quamdiu securitates in forma globali eduntur, investitores indirecti possessores erunt et non possessores iuris praedes.

StreetName Habitum

Wemay terminate a global security or issue securities that are not issued in global form. In these cases, investors may choose tohold their securities in their own names or in “street name.” Securities held by an investor in street name wouldbe registered in the name of a bank, broker or other financial institution that the investor chooses, and the investor would holdonly a beneficial interest in those securities through an account he or she maintains at that institution.

Forsecuritates in vico nomine habitas nos vel quivis commissarius vel depositarius tantum agnoscemus intermedias ripas, sectores et alia pecuniaria instituta, in quorum nominibus cautiones nominantur tanquam possessores illarum cautionum, et nos vel quilibet fideiussor vel depositarius omnes solutiones faciemus super illas praedes illis. Haec instituta transeunt per solutiones accipientes clientibus suis qui sunt dominos utiles, sed solum quia in pactis emptoribus conveniunt vel quia hoc iure requiruntur. Investores qui cautiones in vico nomine tenent, possessores indirecti erunt, non juris possessores, praedes eorum.

LegalHolders

Ourobligations, as well as the obligations of any applicable trustee or third party employed by us or a trustee, run only to thelegal holders of the securities. We do not have obligations to investors who hold beneficial interests in global securities, instreet name or by any other indirect means. This will be the case whether an investor chooses to be an indirect holder of a securityor has no choice because we are issuing the securities only in global form.

Exempli gratia, cum solutionem facimus vel notitiam possessori exhibemus, nullam habemus amplius responsabilitatem solutionis vel noticii, etiamsi possessor exigitur, sub pactis cum suis participantibus vel clientibus vel iure, eam transire ad possessores indirectos. non faciat. Similiter obtinere volumus approbationem tenentium ad emendandam cirographum, ad levandum nos de consecutione defaltae vel de obligatione nostra, ut particulari praescripto cirographo, vel ad alios usus. In quo casu tantum approbationem petimus a detentoribus legalibus, non autem indirectis possessoribus, de pignoribus. An et quomodo iurisperiti indirectos tenentes attingunt usque ad detentores legales.

SpecialConsiderations for Indirect Holders

Ifyou hold securities through a bank, broker or other financial institution, either in book-entry form because the securities arerepresented by one or more global securities or in street name, you should check with your own institution to find out:

GlobalSecurities

Aglobal security is a security that represents one or any other number of individual securities held by a depositary. Generally,all securities represented by the same global securities will have the same terms.

Quaelibet securitas edita in forma libri-introitus per securitatem globalem repraesentabitur quam ad, depositum et mandandum in nomine institutionis nummariae vel eius nominatae quem eligimus. In institutione nummaria, quam ad hoc eligimus, depositarius appellatur. Nisi aliter designemus in prospectus applicabili supplemento, Consignatio spera Societatis, Novi Eboraci, NY, quae DTC nota est, erit depositarius pro omnibus cautionibus in forma libri-introversiis edita.

Securitas aglobalis transferri non potest vel inscriptus nomine alicuius alterius quam depositarii, eius nominati vel successorisdepositarii, nisi condiciones speciales terminentur. Eas condiciones infra sub "-Special SituationsWhen A Global Security terminabitur." Propter has dispositiones, depositarius vel nominatus solus dominus descripti et possessor iuris omnium securitates quae per securitatem globalem repraesentatae erunt, et investitores solum commodis commodis in globali securitate possidebunt. Commodum utilitatis habendum est per rationem cum sectore, patrimonio vel alia institutione oeconomica quae vicissim rationem habet cum depositario vel cum alia institutione quae facit. Ita investor cuius securitas per securitatem globalem repraesentatur non erit iuris securitatis possessor, sed tantum indirectus commoditatis in global securitatem.

Ifthe prospectus supplement for a particular security indicates that the security will be issued as a global security, then thesecurity will be represented by a global security at all times unless and until the global security is terminated. If terminationoccurs, we may issue the securities through another book-entry clearing system or decide that the securities may no longer beheld through any book-entry clearing system.

SpecialConsiderations For Global Securities

Asan indirecte possessor, investitor iura ad securitatem globalem pertinentia regitur per regulas rationes instituti collocatoris et depositarii, necnon leges generales ad securitates transferendas. Non agnoscimus possessorem anindirectum ut possessor securitatis et solum de depositario quod securitatem globalem tenet.

Ifsecurities are issued only as global securities, an investor should be aware of the following:

SpecialSituations When A Global Security Will Be Terminated

In paucis singularibus condicionibus infra descriptis, securitas globalis terminabit et utilitates in ea commutabitur pro physica certificata, quae illas utilitates exprimunt. Post hanc commutationem, electio sive securitates tenere directe sive in plateis, erit usque ad investituram. Obsidores consulere debent suas ripas vel sectores cognoscere quomodo habeant utilitates suas insecuritates in nomina propria transferri, ita ut possessores directi erunt. Iura descripsimus possessorum et investitorum platearum supra.

Securitas Aglobalis terminabitur cum peculiares condiciones sequentes occurrunt;

Prospectus supplementum theapplicabile etiam addere potest condiciones adiuncta ad securitatem globalem terminandam, quae solum ad certas cautionum series, quae a prospecto supplemento obductae sunt, applicare potest. Cum securitas globalis terminatur, depositarius, et neque nos, neque aliquis fideicommissarius, responsabilis est decernendi nomina institutionum quae primi directores erunt.

PLANOF DISTRIBUTIO

Wemay sell the securities being offered hereby in one or more of the following ways from time to time:

Securitates de tempore in tempus distribuantur in una vel pluribus negotiis infra plenius explicandis;

In prospecto supplemento exponemus condiciones peculiares cautionum oblationis, inter quas:

Scriptores tantum in supplemento prospectus applicabili nominati sunt auctores securitatium ab illo supplemento prospectus oblatum.

Si notarii in oblatione adhibentur, consensum subscriptorem cum talibus scribentibus exequemur et nomina singulorum subscriptorum nominabimus et condiciones transactionis (including quaslibet infrascriptos infringo et alia verba quae subscriptores et quosvis negotiatores recompensationem constituunt) in prospecto supplemento. Securitates publicas offerri possunt sive per subscriptores syndicatos per underscriptores administrando vel directe per unum vel plures obsidendum argentarium firmum vel alios, ut est designatus. Si syndicatus infrascriptus adhibeatur, in tegumento subscriptorum designabitur administratio. Prospectus supplement. Si underscriptores in venditione adhibentur, cautiones oblatae ab subscriptoribus pro suis rationibus acquirit et fortasse subinde in una vel pluribus negotiis, inter negotia tractata, certo pretio publico orat variante. pretia constituta tempore venditionis. Quaelibet oblatio publica pretium et quaelibet infringo vel concessione concessa vel re- permissa venditori interdum mutari potest. Nisi aliter in prospecto supplemento proponitur, obligationes scribentium ad cautiones redimendas oblatas, praecedentibus condicionibus obnoxiae erunt, et subscriptores omnes cautiones oblatarum, si qui emuntur, redimere debebunt.

Wemay concedunt subscriptoribus optiones ad alias securitates mercandas ad praedes inaugurandas, si quae sunt, in oblatione publica, cum adiectis commissionibus infrascriptis vel infringo, sicut in actis prospecti supplementi exponi potest. Termini cuiuslibet optionis nimis sortiti sunt, in prospectus supplemento pro illis securitatibus exponetur.

Si mango utamur in venditione praedes prolatis secundum prospectum vel prospectum cuiusvis supplementi, praedes praedes dabimus quasi principales. Praedes postea venditor resecare in publicum diversis pretiis possunt a mangone tempore resale determinari. Nomina negotiatorum et verba transactionis prospectus supplementi specificati erunt.

Wemay securitates vendere per se vel per procuratores designando de tempore in tempus. Procuratorem quemlibet in oblatione pignoris venditionis nominabimus et commissiones quaslibet in prospecto supplementi agentis solvemus. Nisi prospectus supplementum aliud enunciat, agens aliquod optimum nisum ad tempus constitutionis suae aget.

Wemay permitto procuratores vel underscriptores ad sollicitandos ab institutis obsidibus ad cautiones redimendas a nobis in pretio publico oblato, quod in prospecto supplemento secundum quod contractus morae partus solvendae ac liberationis tempus praefinitum in futurum providet. Conditiones harum contractuum describemus et commissiones quae ad sollicitationem horum contractuum in prospecto supplemento solvendae sunt.

Iniunctio cum venditione cautionum, subscriptores, negotiatores vel procuratores a nobis vel ab emptoribus communis stirpis, pro quibus procuratores agunt in forma infringo, concessionibus vel commissionibus. Hascuritates subscriptores vendant vel per negotiatores, et qui negotiatores recipiant recompensationem sub forma infringo, concessionibus vel commissionibus subscriptorum vel commissionum ab emptoribus pro quibus procuratores agere possunt. Subscriptores, negotiatores et procuratores, qui in distributione pignoribus et quibusvis institutis investi- toribus vel aliis, qui commune commercium emerint directe et inde securitates renuntient, censeri possunt esse subscriptores, et quascunque infringas vel commissiones ab eis a nobis receptas et quaslibet proficuum. resale communis stirpis ab iis censeri potest infringo et commissionibus subscriptis sub Securities Act.

Wemay procuratores et underscriptores cum indemnificatione praebent contra particularia onera civilia, etiam onera sub Securities Actus, vel collatio respectu solutionum quas procuratores vel underscriptores facere possunt respectu talium onerum. Agentes et subscriptores negotia exercere possunt vel operas praestare pro ^us in communi negotiorum curriculo.

Wemay apud mercatum in mercatura existente mercaturae secundum Regulam 415(a)(4) sub Securitatibus Act. Accedit, cum tribus partibus (inclusa scriptura optionum) negotia inire vel vendere. securitatis not covered by this prospectus to the third parties in privately agi transactions. Si prospectus applicabilis supplementum ad talem transactionem spectat, tertiae partes, iuxta prospectum et prospectus suppeditationis, securitates hoc prospecto et prospecto supplemento opertas vendere possunt. Quod si ita est, tertia pars potest cautionibus a nobis vel aliis mutuatis ad huiusmodi venditiones componendas et cautionibus a nobis receptis utatur ad clausuras quaslibet arcendas. Praedes etiam mutui vel pignoris obducti hoc prospecto et applicabili prospecto supplemento ad tertias partes, qui pignori creditae vendunt vel, in casu defaltae in causa pignoris, pignori obligatum secundum prospectum et prospectum et locum prospectum vendunt. supplementum. Tertia pars in huiusmodi transactionibus venditionis notula erit notabilis in supplemento prospecti applicabili vel in emendatione post-effective.

Securitatum oblatio- rum series, personae oblationem participantes exercere possunt in negotiis quae stabiliunt, obtinent vel aliter annonae securitates afficiunt. Hoc includere potest super- cessiones seu breves cautionum venditiones, quae involvit venditionem a personis plurium pignoribus oblationem quam illis a nobis venditis. In iis circumstantiis, tales praedia vel breves positiones operiant mercando in foro vel exercendo optionem illis personis concessam. Preterea ii persone stabilire vel manutenere precium securitatis per preceptum vel empcionem pignorum in foro aperto vel irrogando penam prebent, per quod vendicio concessiones concessa tounderscriptores vel negotiatores in quacumque oblatione reuocari possunt, si pignores ab eis venditi sint. redimatur in connectionwith stabilization transactions. Effectus harum rerum potest esse ad stabiliendum vel conservandum annonae securitatisat aequalem supra quam aliter in foro praevalet. Talia, si coepta sunt, intermitti possunt in quolibet tempore. Nullam repraesentationem vel praedictionem facimus ad directionem vel magnitudinem ullius effectus, quod res quae supra scriptae sunt, si perficiantur, pretium securitatis nostrae habere possunt.

Nisi aliter in supplemento prospectus applicabilium specificatur, singulae securitatis genus vel series novus exitus nullo mercatu constituto, praeter communem stirpem nostram, quae in Foro Capitali Nasdaq inscribitur. Electi sumus, ut quamlibet aliam classem securitatis in commercio vel mercatu aliquo recensere possimus, sed hoc non obligati sumus. Fieri potest ut unus vel plures inscriptores mercatum faciant in genere vel serie pignoris, sed notarii non obligabuntur ad faciendum et intermittere mercatum aliquo tempore sine noticia. Non possumus certitudinem dare de liquido mercatus negotiandi pro quibusvis pignoribus.

Praedes leges aliquarum civitatum vel regionum Americae, si locum habent, observare cautiones, secundum quod prospectus offertur, in his civitatibus non nisi per descripti vel licentiati sectores vel negotiatores vendentur. Praeterea in aliquibus civitatibus non vendi possunt, nisi descripti vel idonei ad vendendum in statu applicabili vel exemptio a adnotatione vel absolute postulatio praesto sit et exstiterit.

Quilibet scriptor potest agere altioreotment, stabilientes transactiones, brevia tegumenta transactionum et poenae iubet secundum Regulationem M sub Securities Commutatio Actus anni 1934, ut emendatum (in "Act Commutatio"). Overaltment involvessales in excessu oblationis magnitudinis, quae brevem opinionem efficiunt. Res stabilientes permittere iubet ad secuturam subiacendam tamdiu mercari, dum iusa stabiliendi maximum certum non excedunt. Brevis tegumentum negotiorum involvit emptiones harumcuritatum in foro aperto, postquam distributio perficitur ad brevia loca operienda. Poena iubet permittere underwritersto vendi concessionem a mangone vindicare, cum securitates originaliter venditae a mangone emptae sunt in velamento transactionto brevium locorum. Ea res ut pretium praedes alias superiores esse faciat. Si coeptum est, subscriptores aliquas harum actionum aliquo tempore omitti possunt.

Quilibet scribae qui sunt factores idonei mercati in Foro Capitali Nasdaq in foro passivo negotiationes in cautionibus faciendis in Foro Capitali Nasdaq secundum Regulam 103 Regulae M, in negotio diei ante thepricationem oblationis ante initium oblationis seu venditiones praedes. Facitores passivi mercatus necessario volumine ac pretio limitationes parere debent ac passiva fabrilis notari debent. In genere, mercatus passivus factorem suum licitum esse debet suo pretio non in excessu supremi sui iuris ad talem securitatem invitare. Si omnia independentia iubea demitti iubentur infra iussorum fori passivi, tamen iubetur mercatus passivus tunc demitti cum certae emptionis limites superantur.

LEGALMATTERS

Thevaliditas editae cautionum ex hoc nobis reddetur per Sheppard, Mullin, Richter & HamptonLLP, Los Angeles, California. Additiones legales pro nobis vel quibusvis subscriptoribus, negotiatoribus vel procuratoribus, per consilium quod nominabimus in applicatione prospecti supplementi.

PERITIS

Weinberg& Societas, P.A., independentes ratiunculas publicas firmas descripserunt, audiverunt constitutiones nostras nummarias contexuisse sicut Decembris 31, 2019 et 2018, et annis tunc finitis, prout in relatione sua inde exposita est, quae in hocprospecto et alibi in relatione incorporatum est. in adnotatione editio. Nostrae constitutiones nummariae incorporatae sunt per relationem de Weinberg & Societate, P.A. relatione, quae periti in ratione et audiendo auctoritate sua data sunt.

QUICUMQUE MORE INVENIO INFORMATION

Thisprospectus partem constitutionis registrationis de Forma S-3 factam sub Securitatibus Act. Tamquam permissi ab SEC'srules, hoc prospectus et supplementum quodvis prospectus, quae partem enuntiationis adnotationei constituunt, omnes informationes continentes non continentur in enuntiatione adnotatione. Informationes de nobis invenies in adnotatione adscripta. Quaecumque dicta in hoc prospecto vel aliquo prospecto supplemento de documentis legalibus necessario sunt perfecta et documenta quae interposita sunt ut exhibeat cum propositione adnotatione adposita vel aliter cum SEC ad pleniorem intelligentiam documenti vel materiae, legere debes.

Youmay lege et effingo propositionem adnotationem, necnon relationes nostras, declarationes procuratores et alia informationes, in Relatione SEC's Publica in C F Vico, N.E., Washington, D. C. 20549. Sec ad 1-800-SEC voca quaeso. -0330 pro pluribus informationibus de operatione Relationis Publici Cella. SEC locum interretialem conservat quae relationes, procuratores et informationes continet, et alia de quaestionibus quae electronice cum SEC. SEC situs interretialis apud http://www.sec.gov inveniri potest. Exemplaria etiam materiarum consequi potes quae cum SEC e nostro loco reperimus in www.guardionhealth.com.Informatio in nostro loco nullam partem facit, nec ullo modo incorporatur huic prospecto nec fidendum est. in connection with making an investment decision.

INCORPORATIONOF DOCUMENTORUM REFERENTIA

THESEC informationes nos permittit "incorporare referendo" quod cum illis limamus. Incorporationem referens permittit tibi magnas informationes detegere referendo ad alia documenta. Informatio per referenceis pars magna huius prospecti incorporata est, et notitias nos postea cum SEC file sponte renovabimus et informationes supersedetis. Pronuntiationem adnotationem de Forma S-1 interposita sub Securities Act cum SEC respectu securitatis esse propositae secundum prospectum. Prospectus hic certas informationes omittit, quae in adnotatione adiecta sunt, a SEC permissa. Pronuntiationes adnotationes, inclusas exhibitiones, referre debes, pro ulteriori notitia deus et cautiones secundum prospectum oblatum. Quae in hoc prospectu circa praescripta certorum documentorum cum relatione vel incorporatione conectuntur, enuntiatio adnotationes non sunt necessarie perfectae et singulae propositiones ad omnia ea referentia idonei. Exemplaria totius vel cuiuslibet partis adnotationee, inter documenta incorporata referentia vel exhibitione, obtineri possunt in solutione rates praescriptae ad officia SEC quae supra recensita sunt in "Ubi More Information potes invenire". Incorporamus referentes documenta infra recensita, quae cum SEC iam interposita sunt, et documenta omnia postea a nobis proposita iuxta Sectiones 13(a), 13(c), 14 vel 15(d) Acti Exchange, excepto de quacumque portio cuiuslibet futurae relationis vel documenti quod sub tali praescripto non habetur:

1. Societas annua de Forma X-K pro anno finito 31 Decembris 2019;

2. Relationes Societatis Quarterly pro plagis confectis 31 Martii 2020 et 30 Iunii 2020;

3. Societas Current Renuntiationes de Forma 8-K die 1 Aprilis 2020 propositae, 21 Aprilis 2020, 16 Iunii 2020, 23 Iulii 2020, et Septembris4, 2020; et

4. Descriptio societatis communis stirpis quae in Registration Nostro de Forma 8-A12B facta est cum SECON 4 Aprilis, MMXIX.

Wealso incorporamus referentes omnia documenta (praeter Current Renuntiationes sub Item 2.02 vel Item 7.01 formarum 8-K, et exhibentes tali forma interposita, quae ad has res referuntur) postea a nobis interpositae sunt cum Securitatibus et ExchangeCommissione iuxta Sectiones 13 (a), 13(c), 14 vel 15(d) Actus permutationis ante terminationem oblationis harumcuritatum hac prospectus factae (including documenta interposita post datam Registration initialis Statement of which thisprospectus pars est. ac prior efficaciam Registration). Documenta haec includunt relationes periodicas, ut Relationes Annuas de Forma X-K, Quarterly Renuntiationes de Forma X-Q et Renuntiationes Current de Forma 8-K, necnon Procurator constitutionum.

Quae res in hoc prospecto vel in documento incorporata vel incorporari habetur per respectum in prospectus, immutari vel supersedere censetur quatenus enuntiatio in hoc prospecto contenta vel aliqua postea interposita, quae per relationem in incorporari dignatus est. Prospectus hoc mutatum vel excedentem dictum.

Exemplar harum limationum, nullo pretio, scribendo vel telephonio nobis petentibus ad haec verba: Vincent J. Roth, Societatis Generalis Consilii, apud Custos Scientiarum Medicae, Inc., 15150 Avenue of Science, Suite 200, San. Diego, CA 92128; Tel: 858-605-9055. We tenemus locum in https://guardionhealth.com/sec-filings/. Nostras annuos relationes de Forma X-K accedere potes, relationum quartarum formarum 10-Q, relationum currentium de forma 8-K et aliis relationibus interpositae vel ornatae juxta Sectionem 13(a) vel 15(d) de ExchangeActo cum SEC. gratis apud nostrum locum quam primum rationabiliter praestruitur, cum talis materia electronice interponitur, vel instructa est, SEC. Informationes quae in vel per accessum possunt, nostrum locum non incorporatum est per referencein, nec pars huius prospecti est.

$25,000,000

CommonStock

PROSPECTUSSUPPLEMENT